ReviewJournal of orthopaedics
Re-excision after unplanned excision of soft tissue sarcoma: A systematic review and metanalysis. The rationale of systematic re-excision.
Review in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A Systematic Review of the Orthoplastic Approach in Adult Lower Extremity Soft Tissue Sarcoma Flap Reconstruction.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Pooled it
- Limb-Sparing Resection with Prophylactic Tibial Fixation and Medial Gastrocnemius Flap Reconstruction for Recurrent Leiomyosarcoma in a Previously Irradiated Leg: A Case Report.Reports (MDPI) · 2026Article
- Article
- Giant Asymptomatic Intermuscular Lipoma of Right Thigh: Case Report and Review of Literature.Clinical case reports · 2026Article
- Practice Patterns Vary Among Orthopedic, Plastic, and General Surgeons Resecting Soft Tissue Tumors of the Extremities and Pelvis.Journal of surgical oncology · 2026Article
- Unplanned resections in extremity soft tissue sarcomas: higher local recurrence, more complications and less chance of limb preservation.International orthopaedics · 2025Article
- Planned and Unplanned Sarcoma Resections: Comparative Analysis of Local Recurrence, Metastasis, and Mortality.Cancers · 2024Article
- Unplanned Excision of Synovial Sarcoma: Factors Associated with Recurrence and Survival.Cancers · 2024Article
- The impact of margins and re-resection in pediatric synovial sarcoma.Cancer medicine · 2024Article
- Improving Sarcoma Outcomes: Target Trial Emulation to Compare the Impact of Unplanned and Planned Resections on the Outcome.Cancers · 2024Article
- Article
- Article
- Review
- Unplanned Sarcoma Excisions: Understanding How They Happen.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Efficacy and Safety of Adjuvant Radiotherapy in Re-excised Soft-tissue Sarcoma After Unplanned Resection.The oncologist · 2023Article
- Unplanned Excision of Soft Tissue Sarcomas of the Extremities in a Low-to-Middle-Income Country.Annals of surgical oncology · 2023Review
- Review
- Article
- Impact of the unplanned excision on the oncological outcomes of patients with soft tissue sarcomas: a single-center retrospective review of 490 patients.Acta orthopaedica et traumatologica turcica · 2022Article
- Expert consensus on resection of chest wall tumors and chest wall reconstruction.Translational lung cancer research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Soft Tissue Sarcomas (STS) referral centre many patients have already had an incomplete tumour resection. In the majority of specimen, tumoral residual is detected and linked to a worsen prognosis. Systematic surgical re-resection of the scar tissue area is often performed. Some authors suggested to postpone re-resections until a clinically evident local recurrence is detected. A searching strategy was applied to Pubmed-Central and Ovid Medline. Odds ratio (OR) for local recurrence (LR), distant metastasis (MTS) or overall survival (OS) were calculated comparing patients who had tumour residual to people who hadn't. OR of local recurrences, distant metastasis and OS were calculated in planned vs unplanned-excisions groups. OR to develop a metastasis and OS after a local recurrences were calculated. Residual tumour led to an OR for LR of 3,56, OR of MTS was 3,42; OR of decreased OS was 3,42. Having a LR lead to a OR of 1,55 for MTS and to a OR of decreased OS of 2,32. Patients who underwent a re-excision compared to planned surgery did not have an increased OR of LR and had an OR to develop a MTS of 0,56. Our data confirm that there is a strong correlation between local recurrences, distant relapses and overall survival. Although there is a selection bias; this analysis highlights the optimal oncological outcome in patients who underwent re-resection. The rationale for systematic re-resection after unplanned excision of soft tissue sarcomas is very strong and this treatment remains the gold standard of care in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.