Trial reportNature medicine2021
HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults.
Abstract readClinical Trial
In one paragraph
Trial report in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
18.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 98 citations in OpenAlex.
- Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial.Arteriosclerosis, thrombosis, and vascular biology · 2026Trial
- Clinical management of clonal hematopoiesis.Cancer · 2026Review
- Mosaic chromosomal alterations are suppressed in older adults with HIV.Communications biology · 2026Article
- Association of infection frequency and incident clonal hematopoiesis of indeterminant potential.Experimental hematology · 2026Article
- Inflammageing and clonal haematopoiesis interplay and their impact on human disease.Nature reviews. Molecular cell biology · 2026Review
- Clonal Hematopoiesis in HIV and Atherosclerosis, Arterial Inflammation, and Lymph Node Metabolic Activity.medRxiv : the preprint server for health sciences · 2026Article
- Clonal Hematopoiesis of Indeterminate Potential (CHIP): A Model of Mutation-Driven Thromboinflammation.Cancers · 2026Review
- A framework for the molecular identification of CHIP for clinical research.HGG advances · 2026Article
- Review
- Emerging biomarkers for early detection of aplastic anemia in HIV: A narrative review.Medicine · 2026Review
- Article
- Clonal hematopoiesis of indeterminate potential: a multisystem hub bridging hematopoietic dysfunction with non-hematopoietic diseases.Military Medical Research · 2025Review
- Early versus deferred antiretroviral therapy initiation and long-term cardiovascular disease outcomes in people with HIV: The START study.Open forum infectious diseases · 2025Article
- ASXL1 mutation-related clonal hematopoiesis and age-related diseases: clinical evidence and molecular insights.International journal of hematology · 2025Review
- Understanding residual risk of cardiovascular disease in people with HIV.Current opinion in HIV and AIDS · 2025Review
- Detecting and quantifying clonal selection in somatic stem cells.Nature genetics · 2025Article
- Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventions.Molecular and cellular biochemistry · 2025Review
- Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health.Cardiology clinics · 2025Review
- A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis.British journal of haematology · 2025Review
- Editorial: The role of autophagy in cardiovascular disease.Frontiers in cell and developmental biology · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
22 authors at 9 institutions in 1 country.
Nila J Dharan *Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Paul Yeh *Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Mark BlochHoldsworth House Medical Practice, Sydney, New South Wales, Australia.
Miriam M YeungPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9455-1887
David BakerEast Sydney Doctors, Darlinghurst, New South Wales, Australia.
Jerick GuintoPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Norman RothPrahran Market Clinic, Melbourne, Victoria, Australia.
Sarah FtouniPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Katherine OgnenovskaKirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Don SmithAlbion Centre, South Eastern Sydney Local Hospital Network, Sydney, New South Wales, Australia.
Jennifer F HoyDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-6948-7086
Ian WoolleyMonash Infectious Diseases, Monash Health, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-2928-1291
Catherine PellTaylor Square Private Clinic, Darlinghurst, New South Wales, Australia.
David J TempletonKirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2157-9587
Neil FraserPositive Life, Sydney, New South Wales, Australia.
Nectarios RoseKirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Jolie HutchinsonKirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Kathy Petoumenos *Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia. kpetoumenos@kirby.unsw.edu.au.ORCID http://orcid.org/0000-0001-7534-7154
Sarah-Jane Dawson *Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. sarah-jane.dawson@petermac.org.ORCID http://orcid.org/0000-0002-8276-0374
Mark N Polizzotto *Kirby Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia. mpolizzotto@kirby.unsw.edu.au.ORCID http://orcid.org/0000-0002-6446-183X
Mark A Dawson *Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. mark.dawson@petermac.org.ORCID http://orcid.org/0000-0002-5464-5029
ARCHIVE Study Group
UNSW Sydney · AUThe University of Melbourne · AUSt Vincent's Hospital Sydney · AUMonash University · AUPeter MacCallum Cancer Centre · AUMelbourne Clinic · AUMonash Health · AUSydney Local Health District · AUThe University of Sydney · AU
Funding
Howard Hughes Medical Institute
Abstract
People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and cancer, than people without HIV
Indexed as
AgedAgingCardiovascular DiseasesClonal HematopoiesisDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHIVHIV InfectionsHumansInflammationMaleMiddle AgedMutationASXL1 protein, humanDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanProto-Oncogene ProteinsRepressor ProteinsTET2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.