ArticleNature immunology2021
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
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Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
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37citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
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- CD38 endows local antigen-specific TNature immunology · 2026Article
- Pro-Inflammatory c-MetAnnals of neurology · 2026Article
- Longitudinal proteomic profiling of cerebrospinal fluid in untreated multiple sclerosis defines evolving disease biology.Nature communications · 2025Article
- Intrathecally expanded GZMK+/GZMH+ CD8 T cells targeting EBV antigens may reduce severity of Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases.Frontiers in immunology · 2025Review
- Life history of a brain autoreactive T cell: From thymus through intestine to blood-brain barrier and brain lesion.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TNature immunology · 2024Article
- Innate acting memory Th1 cells modulate heterologous diseases.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Same yet different - how lymph node heterogeneity affects immune responses.Nature reviews. Immunology · 2024Review
- Article
- Resident Memory-like CD8Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Brain-to-gut trafficking of alpha-synuclein by CD11cNature communications · 2023Article
- The P2X7 Receptor in Autoimmunity.International journal of molecular sciences · 2023Review
- Article
- Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- GPR43 stimulation on TCRαβJournal of neuroinflammation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 7 institutions in 1 country.
Michael HiltenspergerInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4600-1394
Eduardo BeltránInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.ORCID http://orcid.org/0000-0002-7266-4098
Ravi KantInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Sofia TyystjärviInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5057-1923
Gildas LepennetierInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-1899-3149
Helena Domínguez MorenoInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Isabel J BauerInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.ORCID http://orcid.org/0000-0001-9090-2072
Simon GrassmannInstitute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.
Sebastian JaroschInstitute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2908-8590
Kilian SchoberInstitute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9323-9472
Veit R BuchholzInstitute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-0441-3913
Selin KenetInstitute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
Christiane GasperiDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0524-6005
Rupert ÖllingerInstitute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.
Roland RadInstitute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6849-9659
Andreas MuschaweckhInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6870-1378
Christopher SieInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-8066-7539
Lilian AlyInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7051-124X
Benjamin KnierDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4187-9472
Garima GargInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Ali M AfzaliInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Lisa Ann GerdesInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Tania KümpfelInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Sören FranzenburgInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0001-6374-4910
Naoto KawakamiInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Bernhard HemmerDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-5985-6784
Dirk H BuschInstitute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-8713-093X
Thomas MisgeldInstitute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9875-6794
Klaus DornmairInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.ORCID http://orcid.org/0000-0003-0342-5373
Thomas KornInstitute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. thomas.korn@tum.de.ORCID http://orcid.org/0000-0002-3633-0955
TUM Klinikum · DEInstitute of Medical Microbiology and Hygiene · DELudwig-Maximilians-Universität München · DETechnical University of Munich · DEMunich Cluster for Systems Neurology · DEChristian-Albrechts-Universität zu Kiel · DEGerman Center for Neurodegenerative Diseases · DE
Funding
European Research Council 647215
Abstract
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or 'mixed' priming of helper T cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant of helper T cell-induced immunopathology in remote organs. By site-specific in vivo labeling of antigen-specific T cells in inguinal (i) or gut draining mesenteric (m) lymph nodes, we show that i-T cells and m-T cells isolated from the inflamed central nervous system (CNS) in a model of multiple sclerosis (MS) are distinct. i-T cells were Cxcr6
Indexed as
AutoimmunityCell LineageAdoptive TransferAnimalsBrainCalcium SignalingCerebrospinal FluidEncephalomyelitis, Autoimmune, ExperimentalFingolimod HydrochlorideGene Expression ProfilingGenes, T-Cell ReceptorHEK293 CellsHumansImmunosuppressive AgentsIntestinesIntravital MicroscopyCxcr6 protein, mouseFingolimod HydrochlorideImmunosuppressive AgentsP2rx7 protein, mouseReceptors, CXCR6Receptors, Purinergic P2X7
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.