SynthesisMolecular psychiatry2021
Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health.
Synthesis in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evening types as determined by subjective and objective measures are more emotional eaters.Obesity (Silver Spring, Md.) · 2023Pooled it
- Report from a randomized control trial: improved alignment between circadian biology and sleep-wake behavior as a mechanism of depression symptom improvement in evening-type adolescents with depressive symptoms.Journal of child psychology and psychiatry, and allied disciplines · 2023Trial
- Exploration and Validation of the Diagnostic Potential of the Circadian Rhythm-Related Genes CCL23 and VNN1 in Adolescents with Depressive Disorder.Molecular neurobiology · 2026Article
- Does later chronotype cause poorer adolescent mental health? An Adolescent Brain Cognitive Development (ABCD) Study.medRxiv : the preprint server for health sciences · 2025Article
- Optimal sleep timing revealed: a new perspective on reducing all-cause mortality and cardiovascular disease-cause mortality in older adults.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- The relationship between chronotype, insomnia and depressive symptoms in Chinese male prisoners.BMC psychiatry · 2025Article
- Cross-sectional relationships of circadian misalignment and rest-activity rhythms with occupational attainment in UK Biobank participants.Chronobiology international · 2025Article
- Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.Nature communications · 2024Article
- Exploring the Causal Association between Morning Diurnal Preference and Psychiatric Disorders: A Bidirectional Two-Sample Mendelian Randomization Analysis.Life (Basel, Switzerland) · 2024Article
- Shared genetic architecture and causal relationship between sleep behaviors and lifespan.Translational psychiatry · 2024Article
- Cortical signatures of sleep are altered following effective deep brain stimulation for depression.Translational psychiatry · 2024Article
- Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index on health outcomes and their interaction in a clinical biobank.medRxiv : the preprint server for health sciences · 2024Article
- Neuropsychiatric disorders, chronotype and sleep: A narrative review of GWAS findings and the application of Mendelian randomization to investigate causal relationships.Genes, brain, and behavior · 2024Review
- Association between mild depressive states in polycystic ovary syndrome and an unhealthy lifestyle.Frontiers in public health · 2024Article
- The causal relationship between sleep and risk of psychiatric disorders: A two-sample mendelian randomization study.Frontiers in genetics · 2024Article
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- Selection of genetic instruments in Mendelian randomisation studies of sleep traits.Sleep medicine · 2023Review
- Mendelian randomization studies of depression: evidence, opportunities, and challenges.Annals of general psychiatry · 2023Review
- Identification and analysis of individuals who deviate from their genetically-predicted phenotype.PLoS genetics · 2023Article
- Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Late diurnal preference has been linked to poorer mental health outcomes, but the understanding of the causal role of diurnal preference on mental health and wellbeing is currently limited. Late diurnal preference is often associated with circadian misalignment (a mismatch between the timing of the endogenous circadian system and behavioural rhythms), so that evening people live more frequently against their internal clock. This study aims to quantify the causal contribution of diurnal preference on mental health outcomes, including anxiety, depression and general wellbeing and test the hypothesis that more misaligned individuals have poorer mental health and wellbeing using an actigraphy-based measure of circadian misalignment. Multiple Mendelian Randomisation (MR) approaches were used to test causal pathways between diurnal preference and seven well-validated mental health and wellbeing outcomes in up to 451,025 individuals. In addition, observational analyses tested the association between a novel, objective measure of behavioural misalignment (Composite Phase Deviation, CPD) and seven mental health and wellbeing outcomes. Using genetic instruments identified in the largest GWAS for diurnal preference, we provide robust evidence that early diurnal preference is protective for depression and improves wellbeing. For example, using one-sample MR, a twofold higher genetic liability of morningness was associated with lower odds of depressive symptoms (OR: 0.92, 95% CI: 0.88, 0.97). It is possible that behavioural factors including circadian misalignment may contribute in the chronotype depression relationship, but further work is needed to confirm these findings.
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