Evidence map›Paper›PMID 34099810›Full record

ArticleScientific reports2021

Colchicine inhibits ROS generation in response to glycoprotein VI stimulation.

G J Pennings, C J Reddel, M Traini, H Campbell, V Chen, L Kritharides

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Biomechanical anticoagulation by spherical platelets in extracorporeal systems.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
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  6. Article
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  8. Article
  9. Article
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  11. Article
  12. Review
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  14. Perspective: Collagen induced platelet activationFrontiers in cardiovascular medicine · 2022
    Article
  15. Colchicine for Coronary Artery Disease: A Review.Frontiers in cardiovascular medicine · 2022
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

G J PenningsThe ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia. gpennings@anzac.edu.au.
C J ReddelThe ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia.
M TrainiThe ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia.
H CampbellThe ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia.
V ChenThe ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia.
L KritharidesThe ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia. leonard.kritharides@sydney.edu.au.
Concord Repatriation General Hospital · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colchicine inhibits coronary and cerebrovascular events in patients with coronary artery disease (CAD), and although known to have anti-inflammatory properties, its mechanisms of action are incompletely understood. In this study, we investigated the effects of colchicine on platelet activation with a particular focus on its effects on activation via the collagen glycoprotein (GP)VI receptor, P2Y

Indexed as

Blood PlateletsCarrier ProteinsColchicineCoronary Artery DiseaseGene Expression RegulationHumansPeptidesPlatelet ActivationPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Membrane GlycoproteinsP-SelectinReactive Oxygen SpeciesReceptors, CollagenSignal TransductionCarrier ProteinsColchicinecollagen-related peptidePeptidesPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Membrane Glycoproteinsplatelet membrane glycoprotein VIP-SelectinReactive Oxygen SpeciesReceptors, CollagenSELP protein, human

Identifiers

PMID34099810
PMCPMC8184800
OpenAlexW3169630123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.