Evidence map›Paper›PMID 34099797›Full record

ArticleScientific reports2021

BSE can propagate in sheep co-infected or pre-infected with scrapie.

Angela Chong, James D Foster, Wilfred Goldmann, Lorenzo Gonzalez, Martin Jeffrey, Matthew J O'Connor, Keith Bishop, Ben C Maddison, E Fiona Houston, Kevin C Gough and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Angela ChongThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
James D FosterThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Wilfred GoldmannThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Lorenzo GonzalezAnimal and Plant Health Agency Lasswade, Pathology Department, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK.
Martin JeffreyAnimal and Plant Health Agency Lasswade, Pathology Department, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK.
Matthew J O'ConnorSchool of Veterinary Medicine and Science, The University of Nottingham, College Road, Sutton Bonington, Loughborough, Leicestershire, LE12 5RD, UK.
Keith BishopADAS Biotechnology, School of Veterinary Medicine and Science, The University of Nottingham, College Road, Sutton Bonington, Loughborough, Leicestershire, LE12 5RD, UK.
Ben C MaddisonADAS Biotechnology, School of Veterinary Medicine and Science, The University of Nottingham, College Road, Sutton Bonington, Loughborough, Leicestershire, LE12 5RD, UK.
E Fiona HoustonThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. Fiona.houston@roslin.ed.ac.uk.
Kevin C GoughSchool of Veterinary Medicine and Science, The University of Nottingham, College Road, Sutton Bonington, Loughborough, Leicestershire, LE12 5RD, UK. Kevin.gough@nottingham.ac.uk.ORCID 0000-0001-5211-2088
Nora HunterThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Roslin Institute · GBUniversity of Nottingham · GBAnimal and Plant Health Agency · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J014508/1
6 · The paper itself

Abstract

To understand the possible role of mixed-prion infections in disease presentation, the current study reports the co-infection of sheep with bovine spongiform encephalopathy (BSE) and scrapie. The bovine BSE agent was inoculated subcutaneously into sheep with ARQ/ARQ or VRQ/ARQ PRNP genotypes either at the same time as subcutaneous challenge with scrapie, or three months later. In addition, VRQ/VRQ sheep naturally infected with scrapie after being born into a scrapie-affected flock were challenged subcutaneously with BSE at eight or twenty one months-of-age. Sheep were analysed by incubation period/attack rate, and western blot of brain tissue determined the presence of BSE or scrapie-like PrP

Indexed as

AnimalsBrainCattleCattle DiseasesCoinfectionEncephalopathy, Bovine SpongiformGenotypePhenotypePrion ProteinsScrapieSheepSheep DiseasesPrion Proteins

Identifiers

PMID34099797
PMCPMC8184847
OpenAlexW3164244566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.