Evidence map›Paper›PMID 34099789›Full record

ArticleScientific reports2021

Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis.

Hsin-Jou Kao, Yan-Han Wang, Sunita Keshari, John Jackson Yang, Shinta Simbolon, Chun-Chuan Chen, Chun-Ming Huang

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. SkinApplied and environmental microbiology · 2026
    Article
  3. Acne vaccine targetingBiotechnologia · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. DistinctFrontiers in microbiomes · 2024
    Article
  11. CommensalScience advances · 2023
    Article
  12. Antibiotics (Basel, Switzerland) · 2023
    Article
  13. Review
  14. Nutrients · 2023
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsin-Jou KaoDepartment of Biomedical Sciences and Engineering, National Central University, Zhongda Rd, No. 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan, ROC.
Yan-Han WangDepartment of Dermatology, University of California, San Diego, CA, USA.
Sunita KeshariDepartment of Life Sciences, National Central University, Zhongli District, Taoyuan City, Taiwan, ROC.
John Jackson YangDepartment of Life Sciences, National Central University, Zhongli District, Taoyuan City, Taiwan, ROC.
Shinta SimbolonDepartment of Biomedical Sciences and Engineering, National Central University, Zhongda Rd, No. 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan, ROC.
Chun-Chuan ChenDepartment of Biomedical Sciences and Engineering, National Central University, Zhongda Rd, No. 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan, ROC.
Chun-Ming HuangDepartment of Biomedical Sciences and Engineering, National Central University, Zhongda Rd, No. 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan, ROC. chunmingsd@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultraviolet irradiation induces melanin accumulation, which can be reduced by the use of chemical whitening products. However, the associated safety concerns of such products have prompted the search for natural and harmless alternatives. This study aimed to identify a natural acidic formulation to reduce skin pigmentation. The metabolite propionic acid (CH

Indexed as

AnimalsCell ProliferationEarFemaleFermentationHumansHyperpigmentationMelaninsMelanocytesMetabolomeMiceMice, Inbred ICRPhotochemical ProcessesPropionatesPropionibacterium acnesReceptors, G-Protein-CoupledFfar2 protein, mouseMelaninsPropionatespropionic acidReceptors, G-Protein-Coupled

Identifiers

PMID34099789
PMCPMC8184931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.