Evidence map›Paper›PMID 34099719›Full record

ArticleNature communications2021

GATA3 induces mitochondrial biogenesis in primary human CD4

Lauren A Callender, Johannes Schroth, Elizabeth C Carroll, Conor Garrod-Ketchley, Lisa E L Romano, Eleanor Hendy, Audrey Kelly, Paul Lavender, Arne N Akbar, J Paul Chapple and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Persistent CD4Cellular immunology · 2026
    Article
  2. Antiviral CD4Communications medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Immunosenescence of T cells: a key player in rheumatoid arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Lauren A Callender *William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Johannes Schroth *William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Elizabeth C CarrollWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Conor Garrod-KetchleyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-0548-5057
Lisa E L RomanoWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Eleanor HendyPeter Gorer Department of Immunobiology and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
Audrey KellyPeter Gorer Department of Immunobiology and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
Paul LavenderPeter Gorer Department of Immunobiology and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
Arne N AkbarDivision of Infection and Immunity, Department of Immunology, University College London, London, UK.ORCID 0000-0002-3763-9380
J Paul ChappleWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sian M HensonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. s.henson@qmul.ac.uk.ORCID 0000-0003-1893-4912
Queen Mary University of London · GBKing's College London · GBUniversity College London · GB

Funding

British Heart Foundation FS/15/69/32043Cancer Research UK C16420/A18066Medical Research Council MR/P00184X/1Wellcome Trust
6 · The paper itself

Abstract

GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4

Indexed as

DNA DamageOrganelle BiogenesisAdultAMP-Activated Protein KinasesCD4-Positive T-LymphocytesCells, CulturedCell SurvivalGATA3 Transcription FactorGene Expression RegulationHumansMiddle AgedMitochondriaNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPrimary Cell CultureAMP-Activated Protein KinasesGATA3 protein, humanGATA3 Transcription FactorNFE2L2 protein, humanNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, human

Identifiers

PMID34099719
PMCPMC8184923
OpenAlexW3170356275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.