ArticleNature communications2021
A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 79 citations in OpenAlex.
- An integrated molecular cytogenetic platform enables precise characterization of Thinopyrum ponticum chromatin and its structural modifications in wheat background.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes.Plant biotechnology journal · 2026Article
- WheatRPred: deep learning framework for predicting disease resistance protein in wheat and its wild relatives.Journal, genetic engineering & biotechnology · 2026Article
- Advances in plant metabolic engineering through synthetic biology.Frontiers in plant science · 2026Review
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- Introgression of stem rust resistance gene Sr68 from Thinopyrum junceum into wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Molecular characterization of a new wheat-Thinopyrum ponticum translocation line with resistance to stripe rust.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris.PLoS pathogens · 2025Article
- Divergent molecular pathways govern temperature-dependent wheat stem rust resistance genes.Nature communications · 2025Article
- Rapid isolation of Yr9 via MutIsoSeq and QTL analysis of durable stripe rust resistance in wheat cultivar Xingzi 9104.Stress biology · 2025Article
- Progress and innovations of gene cloning in wheat and its close relatives.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Genetic engineering, including genome editing, for enhancing broad-spectrum disease resistance in crops.Plant communications · 2025Review
- Sequencing Trait-Associated Mutations (STAM) to Clone Rust Resistance Genes.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Utilization of theMolecular breeding : new strategies in plant improvement · 2024Review
- Development of wheat-tetraploid Thinopyrum elongatum 4EL small fragment translocation lines with stripe rust resistance gene Yr4EL.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Exploring the Frontier of Wheat Rust Resistance: Latest Approaches, Mechanisms, and Novel Insights.Plants (Basel, Switzerland) · 2024Review
- Mapping and Candidate Gene Analysis of an All-Stage Stem Rust Resistance Gene in Durum Wheat Landrace PI 94701.Plants (Basel, Switzerland) · 2024Article
- A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew.Nature communications · 2024Article
- Genome-wide atlas of rust resistance loci in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Identification of candidate genes for adult plant stripe rust resistance transferred from Aegilops ventricosa 2NTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
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Authors and funding
25 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The re-emergence of stem rust on wheat in Europe and Africa is reinforcing the ongoing need for durable resistance gene deployment. Here, we isolate from wheat, Sr26 and Sr61, with both genes independently introduced as alien chromosome introgressions from tall wheat grass (Thinopyrum ponticum). Mutational genomics and targeted exome capture identify Sr26 and Sr61 as separate single genes that encode unrelated (34.8%) nucleotide binding site leucine rich repeat proteins. Sr26 and Sr61 are each validated by transgenic complementation using endogenous and/or heterologous promoter sequences. Sr61 orthologs are absent from current Thinopyrum elongatum and wheat pan genome sequences, contrasting with Sr26 where homologues are present. Using gene-specific markers, we validate the presence of both genes on a single recombinant alien segment developed in wheat. The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability.
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