Evidence map›Paper›PMID 34099682›Full record

ArticleNature communications2021

Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance.

Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.

  1. Pooled it
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  8. The arsenic proteome in cancer: Unravelling molecular mechanisms of anticancer drugs.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Haibo WangDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Minji WangSchool of Biological Sciences, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.ORCID http://orcid.org/0000-0002-6041-3099
Xiaohan XuDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Peng GaoDepartment of Microbiology, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Zeling XuSchool of Biological Sciences, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Qi ZhangDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Hongyan LiDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Aixin YanSchool of Biological Sciences, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.ORCID http://orcid.org/0000-0003-0310-5492
Richard Yi-Tsun KaoDepartment of Microbiology, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China.
Hongzhe SunDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong S.A.R., People's Republic of China. hsun@hku.hk.ORCID http://orcid.org/0000-0001-6697-6899
State Key Laboratory of Synthetic Chemistry · CNChinese University of Hong Kong · HKUniversity of Hong Kong · HKEast China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid emergence of drug resistant Staphylococcus aureus (S. aureus) poses a serious threat to public health globally. Silver (Ag)-based antimicrobials are promising to combat antibiotic resistant S. aureus, yet their molecular targets are largely elusive. Herein, we separate and identify 38 authentic Ag

Indexed as

Anti-Bacterial AgentsCrystallography, X-RayDrug Resistance, BacterialMetal NanoparticlesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPhosphogluconate DehydrogenaseProteomicsSilverSilver NitrateStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsPhosphogluconate DehydrogenaseSilverSilver Nitrate

Identifiers

PMID34099682
PMCPMC8184742
OpenAlexW3172548148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.