ArticleNature communications2021
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
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- miR-184 modulates Ilp8 to control developmental timing during normal growth conditions and in response to developmental perturbations.Development (Cambridge, England) · 2026Article
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- Triggering and modulation of a complex behavior by a single peptidergic command neuron inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adhesive and mechanical properties of the glue produced by 25 Drosophila species.Scientific reports · 2024Article
- Gross morphology and adhesion-associated physical properties of Drosophila larval salivary gland glue secretion.Scientific reports · 2024Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies.Frontiers in cell and developmental biology · 2023Article
- Review
- A Dilp8-dependent time window ensures tissue size adjustment in Drosophila.Nature communications · 2022Article
- Drosophila Glue: A Promising Model for Bioadhesion.Insects · 2022Review
- Motor dysfunction iniScience · 2022Article
- The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.Nature communications · 2021Article
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Authors and funding
20 authors at 9 institutions in 7 countries.
Funding
Abstract
Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.
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