Evidence map›Paper›PMID 34099642›Full record

ArticleNature communications2021

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E Jansen, Nancy L Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernández and 288 more

Erratum issued 2 registry-linked trialsOpen access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 215 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 8 pooled it
41.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01315639 nacompletednot on this map

Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2010 to 2018Enrolled1,067ConditionsAlzheimer's Disease, Mild Cognitive ImpairmentArmsbiomarkers, MRI and CSF
NCT07516119 recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing Tools That Predict and Stage Mild Cognitive Impairment

TypeobservationalSponsorPrevention Research Consortium Corp.Ran2026 to 2029Enrolled100ConditionsMild Cognitive Impairment (MCI), Alzheimer Dementia (AD), Alzheimer Disease (AD), APOE-4 Positive
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 8 syntheses or guidelines pooled it, 325 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
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  8. Pooled it
  9. Trial
  10. Article
  11. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  12. Review
  13. Review
  14. The role of polygenic risk in Alzheimer's disease prediction for African Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Human IL-34 Deficiency Primes Microglia Toward Alzheimer's Disease-Associated States.medRxiv : the preprint server for health sciences · 2026
    Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

298 authors at 20 institutions in 21 countries.

Itziar de Rojas *Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2148-381X
Sonia Moreno-Grau *Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Niccolo Tesi *Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Benjamin Grenier-Boley *Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Victor Andrade *Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
Iris E Jansen *Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Najada StringaAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6350-452X
Anna ZettergrenNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-7182-8417
Isabel HernándezResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Laura MontrrealResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Carmen AntúnezUnidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Anna AntonellAlzheimer's disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Rick M TankardMathematics and Statistics, Murdoch University, Perth, WA, Australia.ORCID http://orcid.org/0000-0002-8847-9401
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Rebecca SimsDivision of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-3885-1199
Céline BellenguezUniv. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID http://orcid.org/0000-0002-1240-7874
Inés QuintelaGrupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Antonio González-PerezCAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
Miguel CaleroCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-5366-3324
Emilio Franco-MacíasUnidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Juan MacíasUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Rafael BlesaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Laura Cervera-CarlesCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2286-200X
Manuel Menéndez-GonzálezServicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Spain.ORCID http://orcid.org/0000-0002-5218-0774
Ana Frank-GarcíaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Jose Luís RoyoDepartamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
Fermin MorenoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Raquel Huerto VilasUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Miquel BaqueroServei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Mónica Diez-FairenFundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1882-0309
Carmen LageCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-1703-121X
Sebastián García-MadronaHospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
Pablo García-GonzálezResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0125-5403
Emilio Alarcón-MartínResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Sergi ValeroResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Oscar Sotolongo-GrauResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Abbe UllgrenKarolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Stockholm, Sweden.
Adam C NajDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Afina W LemstraAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Alba BenaqueResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Alba Pérez-CordónResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-6028-0791
Alberto BenussiCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-8703-6940
Alberto RábanoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Alessandro PadovaniCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Alessio SquassinaDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0001-7415-7607
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Alfonso Arias PastorUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Almar A L KokAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Alun MeggyUK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.
Ana Belén PastorCIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.ORCID http://orcid.org/0000-0001-9637-4688
Ana EspinosaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Anaïs Corma-GómezUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Angel Martín MontesCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-1694-786X
Ángela SanabriaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Anita L DeStefanoDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Anja SchneiderDepartment of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.
Annakaisa HaapasaloA.I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0003-0959-2957
Anne Kinhult StåhlbomKarolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Stockholm, Sweden.
Anne Tybjærg-HansenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Annette M HartmannMartin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany.
Annika SpottkeGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Arturo Corbatón-AnchueloInstituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Arvid RongveHaugesund Hospital, Helse Fonna, Department of Research and Innovation, Haugesund, Norway.ORCID http://orcid.org/0000-0002-0476-4134
Barbara BorroniCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-9338-9040
Børge G NordestgaardDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1954-7220
Brian W KunkleDr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Camille CharbonnierNormandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, FHU G4 Génomique, F-76000 Rouen, France.
Carla AbdelnourResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Carlo MasulloInstitute of Neurology, Catholic University of the Sacred Heart, School of Medicine, Milan, Italy.
Carmen Martínez RodríguezInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Carmen Muñoz-FernandezServicio de Neurología, Hospital Universitario de Gran Canaria Dr.Negrín, Las Palmas, Spain.
Carole DufouilInserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France.
Caroline GraffKarolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Stockholm, Sweden.
Catarina B FerreiraInstituto de Medicina Molecular João lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Caterina ChillottiUnit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
Chandra A ReynoldsDepartment of Psychology, University of California-Riverside, Riverside, CA, USA.ORCID http://orcid.org/0000-0001-6502-7173
Chiara FenoglioUniversity of Milan, Dino Ferrari Center, Milan, Italy.
Christine Van BroeckhovenVIB Center for Molecular Neurology, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-0183-7665
Christopher ClarkInsititute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-7210-7702
Claudia PisanuDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0002-9151-4319
Claudia L SatizabalDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Clive HolmesDivision of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
Dolores Buiza-RuedaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Dag AarslandDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6314-216X
Dan RujescuMartin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany.
Daniel AlcoleaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-3819-3245
Daniela GalimbertiUniversity of Milan, Dino Ferrari Center, Milan, Italy.ORCID http://orcid.org/0000-0002-9284-5953
David WallonNormandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Neurology and CNR-MAJ, FHU G4 Génomique, F-76000 Rouen, France.ORCID http://orcid.org/0000-0002-2634-7198
Davide SeripaComplex Structure of Geriatrics, Department of Medical Sciences Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Edna GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8505-7265
Efthimios DardiotisSchool of Medicine, University of Thessaly, Larissa, Greece.
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Elio ScarpiniUniversity of Milan, Dino Ferrari Center, Milan, Italy.
Elisa ContiSchool of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience, Milan, Italy.
Elisa RubinoDepartment of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
Ellen GelpiNeurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Eloy Rodriguez-RodriguezCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-7742-677X
Emmanuelle DuronAPHP, Hôpital Brousse, equipe INSERM 1178, MOODS, Villejuif, France.
Eric BoerwinkleSchool of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Evelyn FerriGeriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Fabrizio TagliaviniFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Fahri KüçükaliVIB Center for Molecular Neurology, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3835-9639
Florence PasquierInserm U1172, CHU, DISTAlz, LiCEND, Univ Lille, Lille, France.ORCID http://orcid.org/0000-0001-9880-9788
Florentino Sanchez-GarciaServicio de Inmunología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Francesca MangialascheDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Gaël NicolasHospital de Cabueñes, Gijón, Spain.ORCID http://orcid.org/0000-0001-9391-7800
Geir SelbækNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.ORCID http://orcid.org/0000-0001-6511-8219
Gemma OrtegaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Geneviève ChêneInserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France.
Georgios HadjigeorgiouDepartment of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Giacomina RossiFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Giorgio GiacconeFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Giulia GrandeAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Giuliano BinettiMAC-Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Goran PapenbergAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Harald HampelSorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
Henri BaillyAPHP, Hôpital Broca, Paris, France.
Henrik ZetterbergClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.ORCID http://orcid.org/0000-0003-3930-4354
Hilkka SoininenInstitute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-2785-9937
Ida K KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ignacio AlvarezFundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.ORCID http://orcid.org/0000-0002-8537-3935
Ildebrando AppollonioSchool of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience, Milan, Italy.
Ina GieglingMartin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany.
Ingmar SkoogNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg, Gothenburg, Sweden.
Ingvild SaltvedtDepartment of Geriatrics, Clinic of Medicine, St Olavs Hospital, University Hospital of Trondheim, Trondheim, Norway.ORCID http://orcid.org/0000-0002-7897-9808
Innocenzo RaineroDepartment of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
Irene Rosas AllendeInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Jakub HortMemory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University, Prague, Czech Republic.
Janine Diehl-SchmidDepartment of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jasper Van DongenVIB Center for Molecular Neurology, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-5599-0046
Jean-Sebastien VidalAPHP, Hôpital Broca, Paris, France.ORCID http://orcid.org/0000-0001-6770-0720
Jenni LehtisaloInstitute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-8096-3987
Jonathan L HainesDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4351-4728
Jonathan VogelgsangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.ORCID http://orcid.org/0000-0001-9326-8193
Juan A PinedaUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.ORCID http://orcid.org/0000-0002-3751-0296
Juan ForteaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Julius PoppDepartment of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
Katharina BuergerInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Kevin MorganSchools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-8217-2396
Klaus FließbachDepartment of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.
Kristel SleegersVIB Center for Molecular Neurology, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-0283-2332
Laura Molina-PorcelAlzheimer's disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Lena KilanderDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden.
Leonie WeinholdInstitute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
Lindsay A FarrerDepartments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5533-4225
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Luca KleineidamDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
Lucia FarottiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
Lucilla ParnettiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
Lucio TremolizzoSchool of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience, Milan, Italy.
Lucrezia HausnerDepartment of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Luisa BenussiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Lutz FroelichDepartment of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
M Candida Deniz-NaranjoServicio de Inmunología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Magda Tsolaki1st Department of Neurology Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-2072-8010
Maitée Rosende-RocaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Malin LöwenmarkDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden.
Marc HulsmanAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Marco SpallazziAzienda Ospedaliero-Universitaria, Parma, Italy.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0001-7283-8804
Margaret EsiriNuffield Department of Clinical Neurosciences, Oxford, UK.
María Bernal Sánchez-ArjonaUnidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Maria Carolina DalmassoDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
María Teresa Martínez-LarradInstituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Marina ArcaroFondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Marta Fernández-FuertesUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.ORCID http://orcid.org/0000-0002-0654-387X
Martin IngelssonDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden.
Martin J HerrmannDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
Martin SchererDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Martin VyhnalekMemory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University, Prague, Czech Republic.
Mary H KosmidisLaboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Mary YannakouliaDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Matthias SchmidGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Michael EwersInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.ORCID http://orcid.org/0000-0001-5231-1714
Michael T HenekaDepartment of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.
Michael WagnerDepartment of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2589-6440
Michela ScamosciInstitute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Miren ZulaicaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Montserrat AlegretResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Natalia RobertoResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Natasja M van SchoorAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Nazib M SeiduNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg, Gothenburg, Sweden.
Nerisa BanajLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Nicola J ArmstrongMathematics and Statistics, Murdoch University, Perth, WA, Australia.
Nikolaos Scarmeas1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Norbert ScherbaumLVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Oliver GoldhardtDepartment of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Oliver HanonAPHP, Hôpital Broca, Paris, France.
Oliver PetersDepartment of Psychiatry and Psychotherapy and Experimental and Clinical Research Center (ECRC), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Olivia Anna SkrobotBristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK.
Olivier QuenezNormandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, FHU G4 Génomique, F-76000 Rouen, France.ORCID http://orcid.org/0000-0002-8273-8505
Ondrej LerchMemory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University, Prague, Czech Republic.
Paola BossùExperimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-1432-0078
Paolo CaffarraUnit of Neuroscience, DIMEC, University of Parma, Parma, Italy.
Paolo Dionigi RossiGeriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Paraskevi SakkaAthens Association of Alzheimer's disease and Related Disorders, Athens, Greece.
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Peter A HolmansDivision of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-0870-9412
Peter FischerDepartment of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria.
Peter RiedererCenter of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2442-2094
Rachel MarshallDivision of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Rajesh N KalariaTranslational and Clincial Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Richard MayeuxTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.
Roberta CecchettiInstitute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2452-1500
Sebastiaan EngelborghsCenter for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Seppo HelisalmiInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Sigrid Botne SandoDepartment of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
Silke KernNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg, Gothenburg, Sweden.
Silvana ArchettiDepartment of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy.
Silvia BoschiDepartment of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
Silvia FostinelliMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Silvia GilResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Silvia MendozaAlzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
Simon MeadMRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Simona CicconeGeriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-8140-8061
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Teemu KuulasmaaInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Teodoro Del SerDepartment of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
Thibaud LebouvierInserm U1172, CHU, DISTAlz, LiCEND, Univ Lille, Lille, France.
Thomas PolakDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
Tiia NganduDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Timo GrimmerDepartment of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Valentina BessiDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0002-6176-3584
Valentina Escott-PriceDivision of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-1784-5483
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Vincent DeramecourtInserm U1172, CHU, DISTAlz, LiCEND, Univ Lille, Lille, France.
Wolfgang MaierDepartment of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn, Bonn, Germany.
Xueqiu JianGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-0313-6494
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
EADB contributors
GR@ACE study group
DEGESCO consortium
IGAP (ADGC, CHARGE, EADI, GERAD)
PGC-ALZ consortia
Patrick Gavin KehoeBristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK.ORCID http://orcid.org/0000-0002-7542-1139
Guillermo Garcia-RibasHospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
Pascual Sánchez-JuanCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6081-8037
Pau PastorFundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7493-8777
Jordi Pérez-TurCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9111-1712
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Adolfo Lopez de MunainCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9509-4032
Jose María García-AlbercaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2951-6644
María J BullidoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6477-1117
Victoria ÁlvarezInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Alberto LleóCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-2568-5478
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.ORCID http://orcid.org/0000-0003-4932-7429
Pablo MirCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Miguel MedinaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-7016-5340
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Henne HolstegeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7688-3087
Marta MarquiéResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
María Eugenia SáezCAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.ORCID http://orcid.org/0000-0001-9299-2534
Ángel CarracedoGrupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Philippe AmouyelUniv. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Julie WilliamsDivision of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-4069-0259
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6135-2622
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Karen A MatherCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Raquel Sánchez-ValleAlzheimer's disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Manuel Serrano-RíosInstituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Adelina OrellanaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Lluís TárragaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.ORCID http://orcid.org/0000-0002-1890-4193
Martijn HuismanAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands.
Jordi ClarimónCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Mercè BoadaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2617-3009
Wiesje M van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8766-6224
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.ORCID http://orcid.org/0000-0003-4991-763X
Jean-Charles LambertUniv. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID http://orcid.org/0000-0003-0829-7817
Sven J van der LeeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.ORCID http://orcid.org/0000-0003-1606-8643
Agustín RuizResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain. aruiz@fundacioace.org.ORCID http://orcid.org/0000-0003-2633-2495
Instituto de Salud Carlos III · ESFundació ACE · ESUniversitat Autònoma de Barcelona · ESGerman Center for Neurodegenerative Diseases · DEInserm · FRCardiff University · GBUniversidad de Cantabria · ESUniversity of Eastern Finland · FIAmsterdam Neuroscience · NLConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Perugia · ITAristotle University of Thessaloniki · GRFondazione Santa Lucia · ITAgostino Gemelli University Polyclinic · ITCentro Andaluz de Biología del Desarrollo · ESCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHospital Universitario de Valme · ESUniversidade de Santiago de Compostela · ESUniversity Hospital Mútua de Terrassa · ESUniversity of Bonn · DE

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
THE PURPOSE OF MODIFICATION TO(1)INCREASE EFFORT OF OPTION 2 AND OPTION 3 FOR ICN01AG12100 · NIA · ICELANDIC HEART ASSOCIATION · PI GUDNASON, VILMUNDUR · 2007 to 2012
$18.4M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrderR01AG067501 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2024
$11.7M
Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control SampleU01AG049505 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2014 to 2017
$3.0M
Medical Research Council 503480Medical Research Council G0300429Medical Research Council G0400074Medical Research Council G0502157Medical Research Council G0600237Medical Research Council G0601022Medical Research Council G0801418Medical Research Council G0900652Medical Research Council G0902227Medical Research Council G1100540Medical Research Council G9901400Medical Research Council MC_PC_17112Medical Research Council MC_UU_00024/1Medical Research Council MR/K013041/1Medical Research Council MR/L010305/1Medical Research Council MR/L501517/1Medical Research Council MR/M009076/1Medical Research Council MR/T04604X/1NHLBI NIH HHS R01 HL105756NIA NIH HHS N01AG12100NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG067501NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG058589NIA NIH HHS U24 AG021886NINDS NIH HHS R01 NS017950Wellcome TrustWellcome Trust 082604/2/07/Z
6 · The paper itself

Abstract

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.

Indexed as

Multifactorial InheritanceAgedAged, 80 and overAge of OnsetAlzheimer DiseaseAmyloid beta-Protein PrecursorApolipoproteins ECase-Control StudiesCohort StudiesDatasets as TopicFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHeterozygoteHumansAmyloid beta-Protein PrecursorApolipoproteins EAPP protein, human

Identifiers

PMID34099642
PMCPMC8184987
OpenAlexW3172294552

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