Evidence map›Paper›PMID 34099636›Full record

ArticleCell death & disease2021

Oxytocin receptor induces mammary tumorigenesis through prolactin/p-STAT5 pathway.

Dan Li, Mingjun San, Jing Zhang, Anlan Yang, Wanhua Xie, Yang Chen, Xiaodan Lu, Yuntao Zhang, Mingyue Zhao, Xuechao Feng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  8. Review
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  13. Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Oxytocin in Women's Health and Disease.Frontiers in endocrinology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Dan LiTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.ORCID 0000-0003-4448-5727
Mingjun SanTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Jing ZhangTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Anlan YangTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Wanhua XieThe Precise Medicine Center, Department of Basic Medicine, Shenyang Medical College, Shenyang, Liaoning, 110034, China.
Yang ChenTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Xiaodan LuTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Yuntao ZhangTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Mingyue ZhaoTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China.
Xuechao FengTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China. fengxc997@nenu.edu.cn.
Yaowu ZhengTransgenic Research Center, Northeast Normal University, Changchun, Jilin, 130024, China. zhengyw442@nenu.edu.cn.ORCID 0000-0001-8044-1292
Northeast Normal University · CNShenyang Medical College · CNShanxi University · CNXuzhou Medical College · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81270953Natural Science Foundation of Jilin Province (Natural Science Foundation of Jilin Province of China) 20160101344JC
6 · The paper itself

Abstract

Oxytocin receptor (OXTR) is involved in social behaviors, thermoregulation, and milk ejection, yet little is known about its role in breast cancer. To investigate the role of OXTR in mammary gland development and tumorigenesis, a transgenic mouse model of OXTR overexpression (

Indexed as

AnimalsCarcinogenesisCell Transformation, NeoplasticFemaleHumansLactationMammary Glands, AnimalMammary Neoplasms, ExperimentalMCF-7 CellsMiceMice, Inbred C57BLMice, TransgenicProlactinReceptors, OxytocinSignal TransductionSTAT5 Transcription FactorProlactinReceptors, OxytocinSTAT5 Transcription Factor

Identifiers

PMID34099636
PMCPMC8184747
OpenAlexW3172462500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.