Evidence map›Paper›PMID 34099528›Full record

ArticleNeurology2021

Longitudinal Network Changes and Conversion to Cognitive Impairment in Multiple Sclerosis.

Marijn Huiskamp, Anand J C Eijlers, Tommy A A Broeders, Jasmin Pasteuning, Iris Dekker, Bernard M J Uitdehaag, Frederik Barkhof, Alle-Meije Wink, Jeroen J G Geurts, Hanneke E Hulst and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Marijn HuiskampFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK. m.huiskamp@amsterdamumc.nl.
Anand J C EijlersFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.
Tommy A A BroedersFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.
Jasmin PasteuningFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.
Iris DekkerFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.ORCID 0000-0002-8987-9212
Bernard M J UitdehaagFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.
Frederik BarkhofFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.ORCID 0000-0003-3543-3706
Alle-Meije WinkFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.ORCID 0000-0002-8197-0118
Jeroen J G GeurtsFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.
Hanneke E HulstFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.
Menno M SchoonheimFrom the Department of Anatomy and Neurosciences (M.H., A.J.C.E., T.A.A.B., J.P., J.J.G.G., H.E.H., M.M.S.), Department of Neurology (I.D., B.M.J.U.), and Department of Radiology and Nuclear Medicine (I.D., F.B., A.-M.W.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; and UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK.ORCID 0000-0002-2504-6959
Amsterdam Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize functional network changes related to conversion to cognitive impairment in a large sample of patients with multiple sclerosis (MS) over a period of 5 years.

methodsTwo hundred twenty-seven patients with MS and 59 healthy controls of the Amsterdam MS cohort underwent neuropsychological testing and resting-state fMRI at 2 time points (time interval 4.9 ± 0.9 years). At both baseline and follow-up, patients were categorized as cognitively preserved (CP; n = 123), mildly impaired (MCI;

resultsOver time, 18.9% of patients converted to a worse phenotype; 22 of 123 patients who were CP (17.9%) converted from CP to MCI, 10 of 123 from CP to CI (8.1%), and 12 of 32 patients with MCI converted to CI (37.5%). At baseline, default-mode network (DMN) centrality was higher in CI individuals compared to controls (

conclusionsOf all patients, 19% worsened in their cognitive status over 5 years. Conversion from intact cognition to impairment is related to an initial disturbed functioning of the VAN, then shifting toward DMN dysfunction in CI. Because the VAN normally relays information to the DMN, these results could indicate that in MS normal processes crucial for maintaining overall network stability are progressively disrupted as patients clinically progress.

Indexed as

BrainDisease ProgressionAdultCognitive DysfunctionDefault Mode NetworkFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisNerve NetSeverity of Illness Index

Identifiers

PMID34099528
PMCPMC8397585
OpenAlexW3168748377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.