ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.The Journal of physiology · 2026Article
- STForte: tissue context-specific encoding and consistency-aware spatial imputation for spatially resolved transcriptomics.Briefings in bioinformatics · 2025Article
- Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum.eNeuro · 2025Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.Chemical senses · 2025Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- PKIB, a Novel Target for Cancer Therapy.International journal of molecular sciences · 2024Review
- Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells.PLoS biology · 2024Article
- Dense and Sparse Labelling of Mitral Cells by Oral and Intraperitoneal Routes of Tamoxifen Administration.Methods in molecular biology (Clifton, N.J.) · 2023Article
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Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
In sensory systems of the brain, mechanisms exist to extract distinct features from stimuli to generate a variety of behavioral repertoires. These often correspond to different cell types at various stages in sensory processing. In the mammalian olfactory system, complex information processing starts in the olfactory bulb, whose output is conveyed by mitral cells (MCs) and tufted cells (TCs). Despite many differences between them, and despite the crucial position they occupy in the information hierarchy, Cre-driver lines that distinguish them do not yet exist. Here, we sought to identify genes that are differentially expressed between MCs and TCs of the mouse, with an ultimate goal to generate a cell type-specific Cre-driver line, starting from a transcriptome analysis using a large and publicly available single-cell RNA-seq dataset (Zeisel et al., 2018). Many genes were differentially expressed, but only a few showed consistent expressions in MCs and at the specificity required. After further validating these putative markers using ISH, two genes (i.e.,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.