ArticleChest2021
Pleural Pressure Targeted Positive Airway Pressure Improves Cardiopulmonary Function in Spontaneously Breathing Patients With Obesity.
Article in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Effects of Positive End-expiratory Pressure (PEEP) on Lung and Heart Functions in Spontaneous Breathing Obese Subjects.
Imaging the Respiratory Effects of Truncal Adiposity in Healthy Subjects
Imaging the Respiratory Effects of Truncal Adiposity in Acute Hypoxemic Respiratory Failure
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Transpulmonary Pressure as a Predictor of Successful Lung Recruitment: Reanalysis of a Multicenter International Randomized Clinical Trial.Respiratory care · 2025Trial
- ARDS management beyond the guidelines: a practical physiology-based approach to individualized care.Intensive care medicine · 2026Review
- PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Gaps or paradoxes in clinical responses in obese patients.Intensive care medicine · 2026Article
- Obesity: biomechanical implications for mechanical ventilation.Critical care (London, England) · 2026Review
- A clinical guide to non-invasive respiratory support in acute respiratory failure: ventilation settings, technical optimization and clinical indications.Critical care (London, England) · 2025Review
- Ventilation in the obese: physiological insights and management.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Prophylactic Noninvasive Ventilation after Extubation of Obese Patients.American journal of respiratory and critical care medicine · 2025Article
- Esophageal pressure as estimation of pleural pressure: a study in a model of eviscerated chest.BMC anesthesiology · 2024Article
- The pleural gradient does not reflect the superimposed pressure in patients with class III obesity.Critical care (London, England) · 2024Observational
- Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS: a phase II randomized controlled trial.Annals of intensive care · 2024Article
- Candidacy for Extracorporeal Membrane Oxygenation Should Start with Ventilatory Support Optimization.American journal of respiratory and critical care medicine · 2024Article
- Pleural pressure during sleep in Marfan syndrome: details about the CPAP effect.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Retrospective Review of Transpulmonary Pressure Guided Positive End-Expiratory Pressure Titration for Mechanical Ventilation in Class II and III Obesity.Critical care explorations · 2022Article
- A Physiological Hypothesis to Support the Use of Continuous Positive Airway Pressure at Extubation among Patients with Obesity.American journal of respiratory and critical care medicine · 2022Article
- Reply to FlorioAmerican journal of respiratory and critical care medicine · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIncreased pleural pressure affects the mechanics of breathing of people with class III obesity (BMI > 40 kg/m RESEARCH QUESTION: What are the acute effects of CPAP titrated to match pleural pressure on cardiopulmonary function in spontaneously breathing patients with class III obesity? STUDY DESIGN AND
methodsWe enrolled six participants with BMI within normal range (control participants, group I) and 12 patients with class III obesity (group II) divided into subgroups: IIa, BMI of 40 to 50 kg/m
resultsThe levels of CPAP titrated to match pleural pressure in group I, subgroup IIa, and subgroup IIb were 6 ± 2 cmH
interpretationIn ambulatory patients with class III obesity, CPAP titrated to match pleural pressure decreased work of breathing and improved respiratory mechanics while maintaining hemodynamic stability, without impairing right heart function. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT02523352; URL: www.clinicaltrials.gov.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.