Evidence map›Paper›PMID 34099040›Full record

ArticleMolecular autism2021

Psychometric validation and refinement of the Interoception Sensory Questionnaire (ISQ) in adolescents and adults on the autism spectrum.

Evan Suzman, Zachary J Williams, Jacob I Feldman, Michelle Failla, Carissa J Cascio, Mark T Wallace, Maria Niarchou, James S Sutcliffe, Ericka Wodka, Tiffany G Woynaroski

Open access · goldAbstract read
In one paragraph

Article in Molecular autism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Autistic Adult Online Interoception Feasibility Pilot Program.Occupational therapy international · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Evan Suzman *Graduate Program in Biomedical Sciences, Vanderbilt University, 1215 21st Avenue South, Medical Center East, Room 8310, Nashville, TN, 37232, USA. esuzman@gmail.com.ORCID 0000-0001-5265-336X
Zachary J Williams *Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, Nashville, TN, 37232, USA.ORCID 0000-0001-7646-423X
Jacob I FeldmanDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, Nashville, TN, 37232, USA.
Michelle FaillaCenter for Healthy Aging, Self Management and Complex Care, College of Nursing, The Ohio State University, Columbus, OH, USA.
Carissa J CascioVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Mark T WallaceDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, Nashville, TN, 37232, USA.
Maria NiarchouVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
James S SutcliffeDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Ericka WodkaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tiffany G WoynaroskiDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, Nashville, TN, 37232, USA.
Vanderbilt University · USVanderbilt University Medical Center · USKennedy Krieger Institute · USThe Ohio State University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
Sensorimotor integration governing facial expression production in autism.R01MH102272 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J · 2014 to 2023
$4.3M
Investigating the Phenomenology and Physiologic Underpinnings of Decreased Sound Tolerance in Adults with Autism Spectrum DisorderF30DC019510 · NIDCD · VANDERBILT UNIVERSITY · PI WILLIAMS, ZACHARY JAMES · 2021 to 2024
$163k
NCATS NIH HHS TL1 TR002244NICHD NIH HHS P50 HD103537NICHD NIH HHS U54 HD083211NIDCD NIH HHS F30 DC019510NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIMH NIH HHS R01 MH102272
6 · The paper itself

Abstract

backgroundIndividuals on the autism spectrum are reported to display alterations in interoception, the sense of the internal state of the body. The Interoception Sensory Questionnaire (ISQ) is a 20-item self-report measure of interoception specifically intended to measure this construct in autistic people. The psychometrics of the ISQ, however, have not previously been evaluated in a large sample of autistic individuals.

methodsUsing confirmatory factor analysis, we evaluated the latent structure of the ISQ in a large online sample of adults on the autism spectrum and found that the unidimensional model fit the data poorly. Using misspecification analysis to identify areas of local misfit and item response theory to investigate the appropriateness of the seven-point response scale, we removed redundant items and collapsed the response options to put forth a novel eight-item, five-response choice ISQ.

resultsThe revised, five-response choice ISQ (ISQ-8) showed much improved fit while maintaining high internal reliability. Differential item functioning (DIF) analyses indicated that the items of the ISQ-8 were answered in comparable ways by autistic adolescents and adults and across multiple other sociodemographic groups. LIMITATIONS: Our results were limited by the fact that we did not collect data for typically developing controls, preventing the analysis of DIF by diagnostic status. Additionally, while this study proposes a new 5-response scale for the ISQ-8, our data were not collected using this method; thus, the psychometric properties for the revised version of this instrument require further investigation.

conclusionThe ISQ-8 shows promise as a reliable and valid measure of interoception in adolescents and adults on the autism spectrum, but additional work is needed to examine its psychometrics in this population. A free online score calculator has been created to facilitate the use of ISQ-8 latent trait scores for further studies of autistic adolescents and adults (available at https://asdmeasures.shinyapps.io/ISQ_score/ ).

Indexed as

Autistic DisorderInteroceptionAdolescentAdultHumansPsychometricsReproducibility of ResultsSurveys and QuestionnairesAutismInteroceptionItem response theoryMeasurementPsychometricReliabilitySensoryValidity

Identifiers

PMID34099040
PMCPMC8185943
OpenAlexW3118288323

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.