ArticleBMC plant biology2021
Genome-wide identification of the Capsicum bHLH transcription factor family: discovery of a candidate regulator involved in the regulation of species-specific bioactive metabolites.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 55 citations in OpenAlex.
- Salicylic Acid-Induced Elicitation of Nepetalactone and Rosmarinic Acid Biosynthesis in Naked Catmint (International journal of molecular sciences · 2026Article
- Spicy genes: mapping quantitative genomic regions and candidate genes for capsaicinoid and capsinoid biosynthesis in pepper.Frontiers in plant science · 2026Review
- The Transcription Factor CaNAC81 Is Involved in the Carotenoid Accumulation in Chili Pepper Fruits.Plants (Basel, Switzerland) · 2025Article
- Strategies to develop climate-resilient chili peppers: transcription factor optimization through genome editing.Planta · 2025Review
- Integrated Transcriptome and Metabolome Analysis Elucidates the Defense Mechanisms of Pumpkin Against Gummy Stem Blight.International journal of molecular sciences · 2025Article
- Identification of the bHLH Transcription Factor Family in Orah Mandarin and the Response ofPlants (Basel, Switzerland) · 2025Article
- Transcriptome and Metabolome Analyses Reveal the Mechanism of Color Differences in Pomegranate (Plants (Basel, Switzerland) · 2025Article
- Integrated metabolome and transcriptome analysis provides clues to fruit color formation of yellow, orange, and red bell pepper.Scientific reports · 2024Article
- The Influence of Different Factors on the Metabolism of Capsaicinoids in Pepper (Plants (Basel, Switzerland) · 2024Review
- Comparative Transcriptome Analysis Reveals Key Functions of MiMYB Gene Family in Macadamia Nut Pericarp Formation.International journal of molecular sciences · 2024Article
- A Comprehensive Genome-Wide Association Study of Carotenoid and Capsaicinoid Contents inInternational journal of molecular sciences · 2023Article
- Transcriptional and Post-Translational Regulation of Plant bHLH Transcription Factors during the Response to Environmental Stresses.Plants (Basel, Switzerland) · 2023Review
- The spatiotemporal profile ofFrontiers in plant science · 2023Article
- Integrated omics analysis identified genes and their splice variants involved in fruit development and metabolites production in Capsicum species.Functional & integrative genomics · 2022Article
- Putative Transcription Factor Genes Associated with Regulation of Carotenoid Biosynthesis in Chili Pepper Fruits Revealed by RNA-Seq Coexpression Analysis.International journal of molecular sciences · 2022Article
- Genome-wide analysis of basic helix-loop-helix (bHLH) transcription factors in Aquilaria sinensis.Scientific reports · 2022Article
- Review
- Genome-Wide Characterization and Analysis of the bHLH Transcription Factor Family inFrontiers in genetics · 2022Article
- Genome-wide analysis of histone acetyltransferase and histone deacetylase families and their expression in fruit development and ripening stage of pepper (Frontiers in plant science · 2022Article
- Transcriptome-wide characterization of bHLH transcription factor genes inFrontiers in plant science · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe basic helix-loop-helix (bHLH) transcription factors (TFs) serve crucial roles in regulating plant growth and development and typically participate in biological processes by interacting with other TFs. Capsorubin and capsaicinoids are found only in Capsicum, which has high nutritional and economic value. However, whether bHLH family genes regulate capsorubin and capsaicinoid biosynthesis and participate in these processes by interacting with other TFs remains unknown.
resultsIn this study, a total of 107 CabHLHs were identified from the Capsicum annuum genome. Phylogenetic tree analysis revealed that these CabHLH proteins were classified into 15 groups by comparing the CabHLH proteins with Arabidopsis thaliana bHLH proteins. The analysis showed that the expression profiles of CabHLH009, CabHLH032, CabHLH048, CabHLH095 and CabHLH100 found in clusters C1, C2, and C3 were similar to the profile of carotenoid biosynthesis in pericarp, including zeaxanthin, lutein and capsorubin, whereas the expression profiles of CabHLH007, CabHLH009, CabHLH026, CabHLH063 and CabHLH086 found in clusters L5, L6 and L9 were consistent with the profile of capsaicinoid accumulation in the placenta. Moreover, CabHLH007, CabHLH009, CabHLH026 and CabHLH086 also might be involved in temperature-mediated capsaicinoid biosynthesis. Yeast two-hybrid (Y2H) assays demonstrated that CabHLH007, CabHLH009, CabHLH026, CabHLH063 and CabHLH086 could interact with MYB31, a master regulator of capsaicinoid biosynthesis.
conclusionsThe comprehensive and systematic analysis of CabHLH TFs provides useful information that contributes to further investigation of CabHLHs in carotenoid and capsaicinoid biosynthesis.
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