Evidence map›Paper›PMID 34098865›Full record

ArticleCellular & molecular biology letters2021

Circular RNA expression profile in transgenic diabetic mouse kidneys.

Xuan Xiong, Changchun Liu, Meiren Shen, Qian Yang, Qiang Zhao, Xiaoyan Li, Xiaoshi Zhong, Zhiwei Wang

Open access · goldAbstract readLetter
In one paragraph

Article in Cellular & molecular biology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xuan XiongDepartment of Nephrology, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.
Changchun LiuDepartment of Nephrology, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.
Meiren ShenDepartment of Nephrology, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.
Qian YangDepartment of Nephrology, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.
Qiang ZhaoDepartment of Cardiology, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.
Xiaoyan LiLaboratory Medicine Centre, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.
Xiaoshi ZhongDepartment of Nephrology, Guangzhou Red Cross Hospital, Medical School of Jinan University, Guangzhou, 510220, China. zxshhyy@ext.jnu.edu.cn.
Zhiwei WangLaboratory Medicine Centre, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China. wangzhiwei_001@sina.com.
Guangzhou Medical University · CNThe First People's Hospital of Shunde · CNJinan University · CN

Funding

Guangzhou Medical Science and Technology Project No. 20181A011018
6 · The paper itself

Abstract

backgroundDiabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNAs (circRNAs) play crucial regulatory roles in numerous human diseases and normal physiology; however, to date, no study has focused on the comprehensive expression profile of circRNAs in the kidneys of diabetic mice. Therefore, we aimed to identify differentially expressed circRNAs in diabetic mouse kidneys to explore the possible roles of dysregulated circRNAs in diabetic nephropathy development.

resultsDiabetic BKS-Lepr

conclusionWe studied the circRNA expression profile in the kidneys of diabetic mice. Differentially expressed circRNAs may be useful as candidate biomarkers for diabetic nephropathy. Collectively, our results provide a novel theoretical basis for further investigation of the regulatory roles of circRNA in the etiology and pathogenesis of diabetic nephropathy.

Indexed as

TranscriptomeAnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesDown-RegulationKidneyMiceMice, Inbred C57BLMice, TransgenicRNA, CircularUp-RegulationRNA, CircularCircular RNADiabetic nephropathyGene ontology analysismiRNA targetPathway analysis

Identifiers

PMID34098865
PMCPMC8182942
OpenAlexW3168576046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.