Evidence map›Paper›PMID 34098740›Full record

ArticleJournal of the American Heart Association2021

Sex-Based Differences in Bleeding Risk After Percutaneous Coronary Intervention and Implications for the Academic Research Consortium High Bleeding Risk Criteria.

Alessandro Spirito, Felice Gragnano, Noé Corpataux, Lukas Vaisnora, Roberto Galea, Stefano Svab, Giuseppe Gargiulo, George C M Siontis, Fabien Praz, Jonas Lanz and 12 more

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Trial
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  6. Article
  7. Comparison of transjugular and transfemoral approaches for leadless pacemaker implantation in Asian patients: an exploratory study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
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  17. OCEANIC-AF trial: factor XI inhibitors revolution in atrial fibrillation is on hold.European heart journal. Cardiovascular pharmacotherapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alessandro SpiritoDepartment of Cardiology Bern University Hospital Bern Switzerland.
Felice GragnanoDepartment of Cardiology Bern University Hospital Bern Switzerland.
Noé CorpatauxDepartment of Cardiology Bern University Hospital Bern Switzerland.
Lukas VaisnoraDepartment of Cardiology Bern University Hospital Bern Switzerland.
Roberto GaleaDepartment of Cardiology Bern University Hospital Bern Switzerland.
Stefano SvabDepartment of Cardiology Bern University Hospital Bern Switzerland.
Giuseppe GargiuloDepartment of Advanced Biomedical Sciences Federico II University of Naples Naples Italy.
George C M SiontisDepartment of Cardiology Bern University Hospital Bern Switzerland.
Fabien PrazDepartment of Cardiology Bern University Hospital Bern Switzerland.
Jonas LanzDepartment of Cardiology Bern University Hospital Bern Switzerland.
Michael BillingerDepartment of Cardiology Bern University Hospital Bern Switzerland.
Lukas HunzikerDepartment of Cardiology Bern University Hospital Bern Switzerland.
Stefan StorteckyDepartment of Cardiology Bern University Hospital Bern Switzerland.
Thomas PilgrimDepartment of Cardiology Bern University Hospital Bern Switzerland.
Davide CapodannoDivision of Cardiology Azienda Ospedaliero Universitaria "Policlinico-Vittorio Emanuele" University of Catania Catania Italy.
Philip UrbanLa Tour Hospital Geneva Switzerland.
Stuart PocockLondon School of Hygiene and Tropical Medicine London United Kingdom.
Roxana MehranZena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.
Dik HegClinical Trial Unit Bern University of Bern Switzerland.
Stephan WindeckerDepartment of Cardiology Bern University Hospital Bern Switzerland.
Lorenz RäberDepartment of Cardiology Bern University Hospital Bern Switzerland.
Marco ValgimigliDepartment of Cardiology Bern University Hospital Bern Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Female sex was not included among the high bleeding risk (HBR) criteria by the Academic Research Consortium (ARC) as it remains unclear whether it constitutes an HBR condition after percutaneous coronary intervention. We investigated whether female sex associates with HBR and assessed the performance of ARC HBR criteria separately in women and men. Methods and Results Among all consecutive patients undergoing percutaneous coronary intervention between 2009 and 2018, bleeding occurrences up to 1 year were prospectively collected and centrally adjudicated. All but one of the originally defined ARC HBR criteria were assessed, and the ARC HBR score generated accordingly. Among 16 821 patients, 25.6% were women. Compared with men, women were older and had lower creatinine clearance and hemoglobin values. After adjustment, female sex was independently associated with access-site (adjusted hazard ratio, 2.14; 95% CI, 1.22-3.74;

Indexed as

AgedAged, 80 and overFemaleHealth Status DisparitiesHemorrhageHumansMaleMiddle AgedPercutaneous Coronary InterventionProspective StudiesRegistriesRisk AssessmentRisk FactorsSex FactorsSwitzerlandTime FactorsAcademic Research Consortiumbleedingfemale sexpercutaneous coronary interventionvascular access

Identifiers

PMID34098740
PMCPMC8477884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.