Evidence map›Paper›PMID 34098734›Full record

ArticlemBio2021

YeiE Regulates Motility and Gut Colonization in Salmonella enterica Serotype Typhimurium.

T L Westerman, M McClelland, J R Elfenbein

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Molecular strategies ofFrontiers in cellular and infection microbiology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. mBio · 2025
    Article
  7. Naringenin targets FimZ to regulate type I fimbriae and reduce the virulence ofFrontiers in cellular and infection microbiology · 2025
    Article
  8. TheFrontiers in microbiology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Crystal structures of YeiE fromProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

T L WestermanDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
M McClellandDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California, USA.
J R ElfenbeinDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of California, Irvine · US

Funding

Comparative Medicine and Translational Research Training ProgramT32OD011130 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Lauren Virginia Schnabel · 2012 to 2026
$7.8M
Functional dissection of the retron St-85 of Salmonella TyphimuriumK08AI108794 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ELFENBEIN, JOHANNA REBECCA · 2014 to 2017
$602k
Barcoding a Salmonella gene knockout libraryR03AI139557 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MCCLELLAND, MICHAEL · 2019 to 2020
$157k
NIAID NIH HHS K08 AI108794NIAID NIH HHS R03 AI139557NIH HHS T32 OD011130
6 · The paper itself

Abstract

Regulation of flagellum biosynthesis is a hierarchical process that is tightly controlled to allow for efficient tuning of flagellar expression. Flagellum-mediated motility directs Salmonella enterica serovar Typhimurium toward the epithelial surface to enhance gut colonization, but flagella are potent activators of innate immune signaling, so fine-tuning flagellar expression is necessary for immune avoidance. In this work, we evaluate the role of the LysR transcriptional regulator YeiE in regulating flagellum-mediated motility. We show that

Indexed as

Gastrointestinal MicrobiomeGene Expression Regulation, BacterialAnimalsBacterial ProteinsCattleFemaleFlagellaGene ExpressionMiceMice, Inbred C57BLMovementSalmonella Infections, AnimalSalmonella typhimuriumSerogroupVirulenceBacterial Proteinsflagellar gene regulationgastrointestinal infectionhost-pathogen interactionsSalmonellatranscriptional regulation

Identifiers

PMID34098734
PMCPMC8262846
OpenAlexW3167508879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.