Evidence map›Paper›PMID 34098733›Full record

ArticlemBio2021

Loss of the Bacterial Flagellar Motor Switch Complex upon Cell Lysis.

Mohammed Kaplan, Elitza I Tocheva, Ariane Briegel, Megan J Dobro, Yi-Wei Chang, Poorna Subramanian, Alasdair W McDowall, Morgan Beeby, Grant J Jensen

Abstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed KaplanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Elitza I TochevaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Ariane BriegelDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Megan J DobroDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Yi-Wei ChangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Poorna SubramanianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Alasdair W McDowallDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Morgan BeebyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Grant J JensenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

Funding

Structure and Function of Pathogenesis-Associated Bacterial Structures by Electron CryotomographyR01AI127401 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRANT J JENSEN · 2016 to 2026
$3.9M
NIAID NIH HHS R01 AI127401
6 · The paper itself

Abstract

The bacterial flagellar motor is a complex macromolecular machine whose function and self-assembly present a fascinating puzzle for structural biologists. Here, we report that in diverse bacterial species, cell lysis leads to loss of the cytoplasmic switch complex and associated ATPase before other components of the motor. This loss may be prevented by the formation of a cytoplasmic vesicle around the complex. These observations suggest a relatively loose association of the switch complex with the rest of the flagellar machinery.

Indexed as

BacteriaBacterial Physiological PhenomenaBacterial ProteinsFlagellaProtein ConformationBacterial Proteinscell lysiscryo-ETflagellar motorswitch complex

Identifiers

PMID34098733
PMCPMC8263016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.