ArticleThe EMBO journal1988
Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 90 citations in OpenAlex.
- The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution.Nature communications · 2025Article
- Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis.Canadian respiratory journal · 2022Article
- An Inside Job: Applications of Intracellular Single Domain Antibodies.Biomolecules · 2020Review
- Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential.Bioconjugate chemistry · 2019Review
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.The Journal of biological chemistry · 2010Review
- Article
- Site-specific conjugation of HIV-1 tat peptides to IgG: a potential route to construct radioimmunoconjugates for targeting intracellular and nuclear epitopes in cancer.European journal of nuclear medicine and molecular imaging · 2006Article
- Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus.Journal of virology · 1999Article
- Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half.Journal of virology · 1997Article
- MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups.The Journal of clinical investigation · 1997Article
- Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.Journal of virology · 1995Article
- Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1.Journal of virology · 1995Article
- Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection.Journal of virology · 1992Article
- Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor.The EMBO journal · 1992Article
- Disease resistance in farm animals.Experientia · 1991Review
- Molecular and functional analysis of the virus- and interferon-inducible human MxA promoter.Archives of virology · 1991Article
- Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses.The EMBO journal · 1990Article
- Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein.Journal of virology · 1990Article
- Activity of rat Mx proteins against a rhabdovirus.Journal of virology · 1990Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mouse Mx+ cells, interferon alpha/beta induces the synthesis of the nuclear Mx protein, whose accumulation is correlated with specific inhibition of influenza viral protein synthesis. When Mx+ mouse cells are microinjected with the monoclonal anti-Mx antibody 2C12, interferon alpha/beta still induces Mx protein, but no longer inhibits efficiently the expression of influenza viral proteins as visualized by immunofluorescent labeling. However, interferon inhibition of an unrelated control virus, vesicular stomatitis virus, remains unchanged. Proteins with homology to mouse Mx protein are found in interferon-treated cells of a variety of mammalian species. In rat cells, for instance, rat interferon alpha/beta induces three Mx proteins which all cross-react with antibody 2C12 but differ in mol. wt and intracellular location, and it protects these cells well against influenza viruses. However, when rat cells are microinjected with antibody 2C12, interferon alpha/beta cannot induce an efficient antiviral state against influenza virus infection, whereas protection against vesicular stomatitis virus is not altered. These results show that both mouse and rat cells require functional Mx proteins for efficient protection against influenza virus. They further demonstrate that microinjection of antibodies is a promising way of elucidating the role of particular interferon-induced proteins in the intact cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.