ArticleAnnals of coloproctology2021
The Effect of Anastomotic Leakage on the Incidence and Severity of Low Anterior Resection Syndrome in Patients Undergoing Proctectomy: A Propensity Score Matching Analysis.
Article in Annals of coloproctology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Association between anastomotic leak after rectal resection and bowel dysfunction, a systematic review, meta-analysis and meta-regression.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Prevalence and determinants of low anterior resection syndrome following rectal cancer resection: a cross-sectional study.BMC surgery · 2026Article
- Enhancing anastomosis safety with intraoperative perfusion assessment: a visual grading system for tailoring resection and ostomy formation in sigmoid colon and rectal cancer surgery.Annals of coloproctology · 2026Article
- Pre-stoma closure anastomotic leakage severity: Could it explain why late closure increases LARS risk?Updates in surgery · 2026Article
- Knowledge, Attitudes, and Practices Toward LARS Prevention in Rectal Cancer Patients With Prophylactic Stomas: A Multicenter Cross-Sectional Study.Nursing open · 2026Article
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Adenoma and carcinoma in the anal transitional zone following hand-sewn versus stapled ileal pouch-anal anastomosis in familial adenomatous polyposis.Familial cancer · 2025Article
- The Diagnosis and Evolution of Patients with LARS Syndrome: A Five-Year Retrospective Study from a Single Surgery Unit.Cancers · 2024Article
- Predictive factors of major low anterior resection syndrome after surgery for rectal tumors.La Tunisie medicale · 2024Article
- Early detection of anastomotic leakage in colon cancer surgery: the role of early warning score and C-reactive protein.Annals of coloproctology · 2024Article
- The effect of robotic surgery on low anterior resection syndrome in patients with lower rectal cancer: a propensity score-matched analysis.Surgical endoscopy · 2024Article
- Sex Disparities in Rectal Cancer Surgery: An In-Depth Analysis of Surgical Approaches and Outcomes.The world journal of men's health · 2024Review
- How Can We Improve the Tumor Response to Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer?Ewha medical journal · 2023Review
- Surgical Techniques for Transanal Local Excision for Early Rectal Cancer.Ewha medical journal · 2023Review
- Preventing Anastomotic Leakage, a Devastating Complication of Colorectal Surgery.Ewha medical journal · 2023Review
- Fluorescence-guided colorectal surgery: applications, clinical results, and protocols.Annals of surgical treatment and research · 2023Review
- Outcomes following anastomotic leak from rectal resections, including bowel function and quality of life.Annals of coloproctology · 2023Article
- Low anterior resection syndrome: is it predictable?Annals of coloproctology · 2023Article
- Validation of low anterior resection syndrome score in Brazil with Portuguese.Annals of coloproctology · 2023Article
- The status of low anterior resection syndrome: data from a single-center in China.BMC surgery · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProctectomy for the treatment of rectal cancer results in inevitable changes to bowel habits. Symptoms such as fecal incontinence, constipation, and tenesmus are collectively referred to as low anterior resection syndrome (LARS). Among the several risk factors that cause LARS, anastomotic leakage (AL) is a strong risk factor for permanent stoma formation. Therefore, the purpose of this study was to investigate the relationship between the severity of LARS and AL in patients with rectal cancer based on the LARS score and the Memorial Sloan Kettering Cancer Center (MSKCC) defecation symptom questionnaires.
methodsWe retrospectively analyzed patients who underwent low anterior resection for rectal cancer since January 2010. Patients who completed the questionnaire were classified into the AL group and control group based on medical and imaging records. Major LARS and MSKCC scores were analyzed as primary endpoints.
resultsAmong the 179 patients included in this study, 37 were classified into the AL group. After propensity score matching, there were significant differences in the ratio of major LARS and MSKCC scores of the control group and AL group (ratio of major LARS: 11.1% and 37.8%, P<0.001; MSKCC score: 67.29±10.4 and 56.49±7.2, respectively, P<0.001). Univariate and multivariate analyses revealed that AL was an independent factor for major LARS occurrence and MSKCC score.
conclusionThis study showed that AL was a significant factor in the occurrence of major LARS and defecation symptoms after proctectomy.
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