Evidence map›Paper›PMID 34098250›Full record

ArticleBrain and language2021

Dopamine, vocalization, and astrocytes.

Ariana Z Turk, Mahsa Lotfi Marchoubeh, Ingrid Fritsch, Gerald A Maguire, Shahriar SheikhBahaei

Open access · hybridAbstract read
In one paragraph

Article in Brain and language, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  3. A stuttering-associatedbioRxiv : the preprint server for biology · 2025
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  6. Article
  7. Review
  8. Article
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  12. Review
  13. Article
  14. Article
  15. Regulatory mechanisms of dopamine metabolism in a marineSynthetic and systems biotechnology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ariana Z TurkNeuron-Glia Signaling and Circuits Unit, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, 20892 MD, USA.
Mahsa Lotfi MarchoubehDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, 72701 AR, USA.
Ingrid FritschDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, 72701 AR, USA.
Gerald A MaguireDepartment of Psychiatry and Neuroscience, School of Medicine, University of California, Riverside, 92521 CA, USA.
Shahriar SheikhBahaeiNeuron-Glia Signaling and Circuits Unit, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, 20892 MD, USA. Electronic address: SheikhbahaeiS@ninds.nih.gov.
National Institutes of Health · USUniversity of Arkansas at Fayetteville · USUniversity of California, Riverside · US

Funding

Neural correlates for cortical and subcortical control of vocalizationZIANS009420 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SHEIKHBAHAEI, SHAHRIAR · 2020 to 2025
$8.6M
Intramural NIH HHS ZIA NS009420
6 · The paper itself

Abstract

Dopamine, the main catecholamine neurotransmitter in the brain, is predominately produced in the basal ganglia and released to various brain regions including the frontal cortex, midbrain and brainstem. Dopamine's effects are widespread and include modulation of a number of voluntary and innate behaviors. Vigilant regulation and modulation of dopamine levels throughout the brain is imperative for proper execution of motor behaviors, in particular speech and other types of vocalizations. While dopamine's role in motor circuitry is widely accepted, its unique function in normal and abnormal speech production is not fully understood. In this perspective, we first review the role of dopaminergic circuits in vocal production. We then discuss and propose the conceivable involvement of astrocytes, the numerous star-shaped glia cells of the brain, in the dopaminergic network modulating normal and abnormal vocal productions.

Indexed as

AstrocytesDopamineBasal GangliaBrainHumansSpeechDopamineAstrocytesBasal gangliaDopamineGliaSpeechVocalization

Identifiers

PMID34098250
PMCPMC8260450
OpenAlexW3169536899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.