Evidence map›Paper›PMID 34098244›Full record

SynthesisSleep medicine reviews2021

A systematic review of the association between sleep health and stress biomarkers in children.

Monica R Ordway, Eileen M Condon, Bridget Basile Ibrahim, Emily A Abel, Melissa C Funaro, Janene Batten, Lois S Sadler, Nancy S Redeker

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Sleep medicine reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Changes in Sleep of Families After the Arrival of an Autism Service Dog.Journal of autism and developmental disorders · 2026
    Article
  6. Article
  7. Article
  8. [Undiagnosed sleep disorders in children from a hospital in Puebla, Mexico].Revista medica del Instituto Mexicano del Seguro Social · 2025
    Observational
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. Environmental Noise Exposure and Sleep Habits among Children in a Cohort from Northern Spain.International journal of environmental research and public health · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Monica R OrdwayYale University School of Nursing, PO Box 27399, West Haven, CT, 06516-7300, USA; Yale School of Medicine, Department of Pediatrics, New Haven, CT, USA. Electronic address: Monica.Ordway@yale.edu.
Eileen M CondonYale University School of Nursing, PO Box 27399, West Haven, CT, 06516-7300, USA.
Bridget Basile IbrahimYale University School of Nursing, PO Box 27399, West Haven, CT, 06516-7300, USA.
Emily A AbelDepartment of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN, 47907-2055, USA.
Melissa C FunaroHarvey Cushing/John Hay Whitney Medical Library, Yale University, 333 Cedar St., New Haven, CT, 06520-8014, USA.
Janene BattenHarvey Cushing/John Hay Whitney Medical Library, Yale University, 333 Cedar St., New Haven, CT, 06520-8014, USA.
Lois S SadlerYale University School of Nursing, PO Box 27399, West Haven, CT, 06516-7300, USA; Yale Child Study Center, 230 South Frontage Rd., New Haven, CT, 06520, USA.
Nancy S RedekerYale University School of Nursing, PO Box 27399, West Haven, CT, 06516-7300, USA.
Yale University · USState Street (United States) · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Training: Self and Family ManagementT32NR008346 · NINR · YALE UNIVERSITY · PI GREY, MARGARET · 2003 to 2018
$4.7M
Community-Level Effects of Structural Racism on Women's Circadian Rhythm Pattern and HeatlhR00NR018876 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONDON, EILEEN · 2021 to 2023
$958k
Sleep, Biological Stress, and Health among Toddlers Living in Socioeconomically Disadvantaged HomesK23NR016277 · NINR · YALE UNIVERSITY · PI ORDWAY, MONICA ROOSA · 2016 to 2018
$457k
Biological, Behavioral, and Genetic Mechanisms in the Intergenerational Transmission of Toxic StressK99NR018876 · NINR · YALE UNIVERSITY · PI CONDON, EILEEN · 2019 to 2020
$180k
NCATS NIH HHS UL1 TR001863NINR NIH HHS K23 NR016277NINR NIH HHS K99 NR018876NINR NIH HHS R00 NR018876NINR NIH HHS T32 NR008346
6 · The paper itself

Abstract

Sleep is intimately linked with the stress response system. While the evidence for this connection has been systematically reviewed in the adult literature, to our knowledge no studies have examined this relationship in young children. Recent scientific interest in understanding the effects of adverse environments in early childhood, including an emphasis on understanding the role of sleep, highlights the importance of synthesizing the current evidence on the relationship between sleep and the stress response system in early childhood. The aim of this systematic review is to examine the relationship between sleep health and biomarkers of physiologic stress (neuroendocrine, immune, metabolic, cardiovascular) in healthy children ages 0-12 y. Following PRISMA guidelines, we identified 68 empirical articles and critically reviewed and synthesized the results across studies. The majority of studies included school-age children and reported sleep dimensions of duration or efficiency. Overall, evidence of associations between sleep health and stress biomarkers was strongest for neuroendocrine variables, and limited or inconsistent for studies of immune, cardiovascular, and metabolic outcomes. Gaps in the literature include prospective, longitudinal studies, inclusion of children under the age of 5 y, and studies using objective measures of sleep.

Indexed as

SleepAdultBiomarkersChildChild, PreschoolHumansInfantInfant, NewbornProspective StudiesBiomarkersBiomarkersHealthy brain and child development studyPediatricsPhysiological stressSleepSleep healthStressStress responseSystematic reviewToxic stress

Identifiers

PMID34098244
PMCPMC8458225
OpenAlexW3162582339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.