ArticleHeart & lung : the journal of critical care
High-flow Nasal Cannula therapy: A feasible treatment for vulnerable elderly COVID-19 patients in the wards.
Article in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Frailty as a Predictor of Outcomes in Optiflow.Cureus · 2025Article
- High-flow nasal oxygen vs. conventional oxygen therapy in patients with COVID-19 related acute hypoxemic respiratory failure and a do not intubate order: a multicentre cohort study.Respiratory research · 2025Observational
- Use of high flow nasal cannula oxygen therapy for patients infected with SARS-CoV-2 outside intensive care setting.Journal of thoracic disease · 2023Article
- Severe COVID-19 Pneumonia in Elderly Patients: Success Rate of Compassioned Use of High Flow Nasal Cannula Therapy.Aging and disease · 2023Article
- Continuous Positive Airway Pressure in Elderly Patients with Severe COVID-19 Related Respiratory Failure.Journal of clinical medicine · 2022Article
- Factors associated with failure of high-flow nasal cannula oxygen therapy in patients with severe COVID-19: a retrospective case series.The Journal of international medical research · 2022Article
- Clinical Frailty Scale (CFS) indicated frailty is associated with increased in-hospital and 30-day mortality in COVID-19 patients: a systematic review and meta-analysis.Annals of intensive care · 2022Article
- Lack of Benefit of High Flow Nasal Oxygen Therapy as Ceiling of Treatment for Severe COVID-19 Pneumonitis in Elderly Frail Patients: A Single Centre Observational Study.The open respiratory medicine journal · 2022Article
- The efficiency of high-flow nasal cannula for adult patients with coronavirus disease 19 in Jeddah, Saudi Arabia.Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInvasive mechanical ventilation is the treatment of choice in COVID-19 patients when hypoxemia persists, despite maximum conventional oxygen administration. Some frail patients with severe hypoxemic respiratory failure are deemed not eligible for invasive mechanical ventilation.
objectivesTo investigate whether High-flow nasal cannula (HFNC) in the wards could serve as a rescue therapy in these frail patients.
methodsThis retrospective cohort study included frail COVID-19 patients admitted to the hospital between March 9th and May 1st 2020. HFNC therapy was started in the wards. The primary endpoint was the survival rate at hospital discharge.
resultsThirty-two patients with a median age of 79.0 years (74.5-83.0) and a Clinical Frailty Score of 4 out of 9 (3-6) were included. Only 6% reported HFNC tolerability issues. The overall survival rate was 25% at hospital discharge.
conclusionsThis study suggests that, when preferred, HFNC in the wards could be a potential rescue therapy for respiratory failure in vulnerable COVID-19 patients.
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