Evidence map›Paper›PMID 34097900›Full record

ArticleBehavioural brain research2021

Psychosocial impairment following mild blast-induced traumatic brain injury in rats.

Nicholas S Race, Katharine D Andrews, Elizabeth A Lungwitz, Sasha M Vega Alvarez, Timothy R Warner, Glen Acosta, Jiayue Cao, Kun-Han Lu, Zhongming Liu, Amy D Dietrich and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicholas S RaceWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Medical Scientist Training Program, Indiana University School of Medicine, Indianapolis, IN, USA.
Katharine D AndrewsMedical Scientist Training Program, Indiana University School of Medicine, Indianapolis, IN, USA; Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN, USA.
Elizabeth A LungwitzPaul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN, USA.
Sasha M Vega AlvarezPULSe Interdisciplinary Life Science Program, Purdue University, West Lafayette, IN, USA.
Timothy R WarnerPaul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cellular Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Glen AcostaDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Jiayue CaoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA.
Kun-Han LuPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, USA.
Zhongming LiuWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, USA.
Amy D DietrichPaul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cellular Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Sreeparna MajumdarPaul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN, USA.
Anantha ShekharPaul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
William A TruittPaul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cellular Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: btruitt@iu.edu.
Riyi ShiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; PULSe Interdisciplinary Life Science Program, Purdue University, West Lafayette, IN, USA; Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA; Center for Paralysis Research, West Lafayette, IN, USA. Electronic address: riyi@purdue.edu.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
NEURAL REGULATION OF SOCIAL FAMILIARITY INDUCED ANXIOLYSIS ALZHEIMER S SupplementR01MH106568 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI TRUITT, WILLIAM ANTHONY · 2015 to 2019
$2.8M
Multimodal Hyperspectral Imaging of Brain Activity and ConnectivityR01MH104402 · NIMH · PURDUE UNIVERSITY · PI LIU, ZHONGMING · 2014 to 2018
$2.3M
Biomechanics of Blast InjuryR21NS090244 · NINDS · PURDUE UNIVERSITY · PI SHI, RIYI · 2014 to 2015
$426k
A novel enzymatic mechanism for removing neurotoxic aldehydes after rodent spinal cord injuryR21NS115094 · NINDS · PURDUE UNIVERSITY · PI SHI, RIYI · 2019 to 2020
$424k
NCATS NIH HHS UL1 TR002529NCRR NIH HHS UL1 RR025761NIMH NIH HHS R01 MH104402NIMH NIH HHS R01 MH106568NINDS NIH HHS R21 NS090244NINDS NIH HHS R21 NS115094
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is associated with increased risk for mental health disorders, impacting post-injury quality of life and societal reintegration. TBI is also associated with deficits in psychosocial processing, defined as the cognitive integration of social and emotional behaviors, however little is known about how these deficits manifest and their contributions to post-TBI mental health. In this pre-clinical investigation using rats, a single mild blast TBI (mbTBI) induced impairment of psychosocial processing in the absence of confounding physical polytrauma, post-injury motor deficits, affective abnormalities, or deficits in non-social behavior. Impairment severity correlated with acute upregulations of a known oxidative stress metabolite, 3-hydroxypropylmercapturic acid (3-HPMA), in urine. Resting state fMRI alterations in the acute post-injury period implicated key brain regions known to regulate psychosocial behavior, including orbitofrontal cortex (OFC), which is congruent with our previous report of elevated acrolein, a marker of neurotrauma and 3-HPMA precursor, in this region following mbTBI. OFC of mbTBI-exposed rats demonstrated elevated mRNA expression of metabotropic glutamate receptors 1 and 5 (mGluR1/5) and injection of mGluR1/5-selective agonist in OFC of uninjured rats approximated mbTBI-induced psychosocial processing impairment, demonstrating a novel role for OFC in this psychosocial behavior. Furthermore, OFC may serve as a hotspot for TBI-induced disruption of psychosocial processing and subsequent mental health disorders.

Indexed as

Psychosocial FunctioningAcetylcysteineAcroleinAnimalsBlast InjuriesBrainBrain ConcussionBrain InjuriesDisease Models, AnimalMagnetic Resonance ImagingMalePrefrontal CortexRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateAcetylcysteineAcroleinReceptors, Metabotropic GlutamateS-(3-hydroxypropyl)cysteine N-acetateBlastBrain injuryHead traumaPsychosocialSafety learning

Identifiers

PMID34097900
PMCPMC9284795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.