ArticlePloS one2021
Validation of the World Health Organization/ International Society of Hypertension (WHO/ISH) cardiovascular risk predictions in Sri Lankans based on findings from a prospective cohort study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Comparing Non-Laboratory-Based and Laboratory-Based Cardiovascular Risk Predictions: Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Cardiovascular risk prediction in women with gestational diabetes using risk assessment tools: a scoping review.Diabetology & metabolic syndrome · 2026Article
- Burden of premature atherosclerotic cardiovascular disease and its risk factors among young and middle-aged adults in primary care clinics of Karachi, Pakistan.Journal of health, population, and nutrition · 2026Article
- Unveiling Cardiovascular Risk Among Older Adults in Eastern India: A Community-Based Cross-Sectional Study.Cureus · 2025Article
- Risk prediction of cardiovascular disease in the Asia-Pacific region: the SCORE2 Asia-Pacific model.European heart journal · 2025Article
- Article
- A multidimensional approach to assess cardiovascular disease risk combining biochemical, hematological, lipid ratios, atherosclerotic cardiovascular disease, and WHO/ISH 10-year risk estimators: a cross-sectional study.American journal of cardiovascular disease · 2025Article
- Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.American journal of preventive cardiology · 2024Article
- Development and validation of a cardiovascular risk prediction model for Sri Lankans using machine learning.PloS one · 2024Article
- Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S.JACC. Advances · 2023Article
- Cardiovascular disease risk profile and management among people 40 years of age and above in Bo, Sierra Leone: A cross-sectional study.PloS one · 2022Article
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15 authors.
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Abstract
INTRODUCTION AND
objectivesThere are no cardiovascular (CV) risk prediction models for Sri Lankans. Different risk prediction models not validated for Sri Lankans are being used to predict CV risk of Sri Lankans. We validated the WHO/ISH (SEAR-B) risk prediction charts prospectively in a population-based cohort of Sri Lankans.
methodWe selected 40-64 year-old participants from the Ragama Medical Officer of Health (MOH) area in 2007 by stratified random sampling and followed them up for 10 years. Ten-year risk predictions of a fatal/non-fatal cardiovascular event (CVE) in 2007 were calculated using WHO/ISH (SEAR-B) charts with and without cholesterol. The CVEs that occurred from 2007-2017 were ascertained. Risk predictions in 2007 were validated against observed CVEs in 2017.
resultsOf 2517 participants, the mean age was 53.7 year (SD: 6.7) and 1132 (45%) were males. Using WHO/ISH chart with cholesterol, the percentages of subjects with a 10-year CV risk <10%, 10-19%, 20%-29%, 30-39%, ≥40% were 80.7%, 9.9%, 3.8%, 2.5% and 3.1%, respectively. 142 non-fatal and 73 fatal CVEs were observed during follow-up. Among the cohort, 9.4% were predicted of having a CV risk ≥20% and 8.6% CVEs were observed in the risk category. CVEs were within the predictions of WHO/ISH charts with and without cholesterol in both high (≥20%) and low(<20%) risk males, but only in low(<20%) risk females. The predictions of WHO/ISH charts, with-and without-cholesterol were in agreement in 81% of subjects (ĸ = 0.429; p<0.001).
conclusionsWHO/ISH (SEAR B) risk prediction charts with-and without-cholesterol may be used in Sri Lanka. Risk charts are more predictive in males than in females and for lower-risk categories. The predictions when stratifying into 2 categories, low risk (<20%) and high risk (≥20%), are more appropriate in clinical practice.
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