Evidence map›Paper›PMID 34097603›Full record

ArticleIEEE transactions on bio-medical engineering2022

Photoplethysmography Fast Upstroke Time Intervals Can Be Useful Features for Cuff-Less Measurement of Blood Pressure Changes in Humans.

Keerthana Natarajan, Robert C Block, Mohammad Yavarimanesh, Anand Chandrasekhar, Lalit K Mestha, Omer T Inan, Jin-Oh Hahn, Ramakrishna Mukkamala

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  8. The 2023 wearable photoplethysmography roadmap.Physiological measurement · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Keerthana Natarajan
Robert C Block
Mohammad Yavarimanesh
Anand Chandrasekhar
Lalit K Mestha
Omer T Inan
Jin-Oh Hahn
Ramakrishna Mukkamala
Michigan State University · USGeorgia Institute of Technology · USMassachusetts Institute of Technology · USPalo Alto Research Center · USUniversity of Maryland, College Park · USUniversity of Pittsburgh · USUniversity of Rochester · US

Funding

Unobtrusive and Affordable Blood Pressure Monitoring Via Pulse Transit TimeU01EB018818 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MUKKAMALA, RAMAKRISHNA · 2014 to 2018
$3.4M
Mobile Device-Based Congestion Prediction for Reducing Hospitalizations in Patients with Concomitant Heart Failure and Atrial FibrillationR21EB027276 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAEED, MOHAMMED · 2019 to 2022
$598k
NIBIB NIH HHS R21 EB027276NIBIB NIH HHS U01 EB018818
6 · The paper itself

Abstract

objectivePhotoplethysmography (PPG) waveform analysis is being increasingly investigated for continuous, non-invasive, and cuff-less blood pressure (BP) measurement. However, the efficacy of this approach and the useful features and models remain largely unclear. The objectives were to develop easy-to-understand models relating PPG waveform features to BP changes (after a cuff calibration) and to determine their value in BP measurement accuracy.

methodsThe study data comprised finger, toe, and ear PPG waveforms, an ECG waveform, and reference manual cuff BP measurements from 32 human subjects (25% hypertensive) before and after slow breathing, mental arithmetic, cold pressor, and nitroglycerin administration. Stepwise linear regression was employed to create parsimonious models for predicting the intervention-induced BP changes from popular PPG waveform features, pulse arrival time (PAT, time delay between ECG R-wave and PPG foot), and subject demographics. Leave-one-subject-out cross validation was applied to compare the BP change prediction root-mean-squared-errors (RMSEs) of the resulting models to reference models in which PPG waveform features were excluded.

resultsFinger b-time (PPG foot to minimum second derivative time interval) and ear "STT" (PPG amplitude divided by maximum derivative), when combined with PAT, reduced the systolic BP change prediction RMSE of reference models by 6-7% (p 0.022). Ear STT together with pulse width reduced the diastolic BP change prediction RMSE of the reference model by 13% (p = 0.003).

conclusionThe two PPG fast upstroke time intervals can offer some added value in cuff-less BP trending. SIGNIFICANCE: This study offers important information towards achieving non-invasive and passive BP monitoring without a cuff.

Indexed as

PhotoplethysmographyPulse Wave AnalysisBlood PressureBlood Pressure DeterminationHeart RateHumans

Identifiers

PMID34097603
PMCPMC8782151
OpenAlexW3168755979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.