ArticleJournal of biopharmaceutical statistics2021
Four-parameter paired response curve for serial dilution assays.
Article in Journal of biopharmaceutical statistics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Newer immunoassay platforms offer improved signal-to-noise ratio but are more expensive. Thus, it is more cost efficient to perform these assays at a few selected, rather than a full series of, sample dilutions. We propose a new four-parameter paired response curve to model the relationship between assay outcomes from two sample dilutions and study likelihood-based inference. Given a fitted paired response curve, we can predict assay outcomes for de novo dilutions of samples, which enables cross-protocol comparison of immune response biomarkers even when different protocols use different sample dilutions. Numerical studies on both simulated and real data are presented.
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