Evidence map›Paper›PMID 34097494›Full record

ArticleAntimicrobial agents and chemotherapy2021

Antibiotic Cycling Reverts Extensive Drug Resistance in Burkholderia multivorans.

L G Kavanaugh, S K Harrison, J N Flanagan, T R Steck

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

L G KavanaughBiochemistry Department, Emory University, Atlanta, Georgia, USA.
S K HarrisonBiological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
J N FlanaganBiological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
T R SteckBiological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
University of North Carolina at Charlotte · US

Funding

Identifying Bacterial Biomarkers Associated with Disease Progression in Cystic FibrosisR15HL126122 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI STECK, TODD R · 2015 to 2015
$453k
HHS | National Institutes of Health (NIH) 1R15HL126122-01NHLBI NIH HHS R15 HL126122
6 · The paper itself

Abstract

Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans. Here, we observed that treatment of extensively drug-resistant variants evolved from a cystic fibrosis (CF) sputum sample isolate with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans.

Indexed as

BurkholderiaBurkholderia cepacia complexBurkholderia InfectionsAnti-Bacterial AgentsDrug ResistanceHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsantibiotic resistanceBurkholderiacollateral sensitivitycombination antibioticsequential therapyXDR

Identifiers

PMID34097494
PMCPMC8284468
OpenAlexW3167920671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.