Evidence map›Paper›PMID 34097460›Full record

ArticleInfection and immunity2021

Immune Inhibitor A Metalloproteases Contribute to Virulence in

Erin T Livingston, Md Huzzatul Mursalin, Phillip S Coburn, Roger Astley, Frederick C Miller, Omar Amayem, Didier Lereclus, Michelle C Callegan

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The Effect ofMicroorganisms · 2026
    Article
  3. Infection and immunity · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Virulence-related genotypic differences amongFrontiers in cellular and infection microbiology · 2023
    Article
  9. Article
  10. Article
  11. Proteomic Characterization of Virulence Factors and Related Proteins inInternational journal of molecular sciences · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Erin T LivingstonDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Md Huzzatul MursalinDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Phillip S CoburnDepartment of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0003-3799-5251
Roger AstleyDepartment of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Frederick C MillerDepartment of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Omar AmayemDepartment of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Didier LereclusMicalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, France.ORCID 0000-0001-9047-9104
Michelle C CalleganDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-1400-8586
University of Oklahoma Health Sciences Center · USAgroParisTech · FRDean McGee Eye Institute · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan · 2011 to 2026
$10.5M
Pathogenic Mechanisms of Bacillus EndophthalmitisR01EY028810 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2018 to 2022
$1.8M
Vascular Permeability and Ocular InfectionsR01EY024140 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2014 to 2017
$1.6M
Nanotherapeutics for Ocular InfectionsR01EY025947 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C, ZHANG, LIANGFANG · 2015 to 2017
$1.1M
Targeting Chemokines in Intraocular InfectionR21EY028066 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2019 to 2020
$399k
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY024140NEI NIH HHS R01 EY025947NEI NIH HHS R01 EY028810NEI NIH HHS R21 EY028066
6 · The paper itself

Abstract

Endophthalmitis is a devastating infection that can cause blindness. Over half of

Indexed as

AnimalsBacillus thuringiensisCells, CulturedDisease Models, AnimalEndophthalmitisEye Infections, BacterialHumansInflammationMetalloendopeptidasesMetalloproteasesMiceMice, Inbred C57BLRetinaVirulenceimmune inhibitor AMetalloendopeptidasesMetalloproteasesBacillusendophthalmitisimmune inhibitor Ametalloproteases

Identifiers

PMID34097460
PMCPMC8447934
OpenAlexW3169389157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.