Evidence map›Paper›PMID 34097381›Full record

ArticleJournal of the American Chemical Society2021

Turnover and Inactivation Mechanisms for (

Sida Shen, Arseniy Butrin, Peter F Doubleday, Rafael D Melani, Brett A Beaupre, Mauricio T Tavares, Glaucio M Ferreira, Neil L Kelleher, Graham R Moran, Dali Liu and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Inactivation of ornithine aminotransferase by (1Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  4. Synthesis of (2The Journal of organic chemistry · 2024
    Article
  5. Article
  6. Information-Rich, Dual-FunctionJournal of the American Chemical Society · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sida ShenDepartment of Chemistry, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-0295-2545
Arseniy ButrinDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Peter F DoubledayDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
Rafael D MelaniDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
Brett A BeaupreDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Mauricio T TavaresDepartment of Molecular Medicine, Scripps Research, Jupiter, Florida 33458, United States.
Glaucio M FerreiraDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.ORCID 0000-0002-1952-9428
Neil L KelleherDepartment of Chemistry, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-8815-3372
Graham R MoranDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.ORCID 0000-0002-6807-1302
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.ORCID 0000-0002-7587-703X
Richard B SilvermanDepartment of Chemistry, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-9034-1084
Northwestern University · USLoyola University Chicago · USScripps Research Institute · USUniversidade de São Paulo · BR

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
New Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0M
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of CancersR01CA260250 · NCI · NORTHWESTERN UNIVERSITY · PI RICHARD B SILVERMAN · 2021 to 2026
$2.3M
NCI NIH HHS R01 CA260250NIDA NIH HHS P30 DA018310NIDA NIH HHS R01 DA030604
6 · The paper itself

Abstract

The inhibition of human ornithine δ-aminotransferase (

Indexed as

HumansMolecular StructureOrnithine-Oxo-Acid TransaminaseOAT protein, humanOrnithine-Oxo-Acid Transaminase

Identifiers

PMID34097381
PMCPMC8367020
OpenAlexW3167679164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.