ArticleAnnals of intensive care2021
Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Guideline
- Global prevalence and effect of comorbidities and smoking status on severity and mortality of COVID-19 in association with age and gender: a systematic review, meta-analysis and meta-regression.Scientific reports · 2023Pooled it
- Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2022Pooled it
- [Driving pressure-guided lung protective ventilation strategy reduces postoperative pulmonary complications in patients recovered from COVID-19].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Trial
- Prediction of intensive care admission and hospital mortality in COVID-19 patients using demographics and baseline laboratory data.Clinics (Sao Paulo, Brazil) · 2023Trial
- Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial.Critical care (London, England) · 2022Trial
- Emerging trends and hotspots in lung-protective ventilation from 2006 to 2025: a bibliometric analysis.Journal of thoracic disease · 2026Article
- Preferences for mechanical ventilation modes among intensivists in Türkiye: a nationwide point-prevalence study.Turkish journal of medical sciences · 2026Article
- Article
- Predictive Performance of SAPS-3, SOFA Score, and Procalcitonin for Hospital Mortality in COVID-19 Viral Sepsis: A Cohort Study.Life (Basel, Switzerland) · 2025Article
- Discordance between physical and cognitive health problems over one year after critical care: Insights from severe COVID-19 patients.The journal of nutrition, health & aging · 2025Article
- Epidemiology, Ventilation Management, and Outcomes in Invasively Ventilated Coronavirus Disease 2019 Patients: An Analysis of Four Observational Studies in Four Countries on Two Continents.The American journal of tropical medicine and hygiene · 2025Observational
- Neuroleptics used in critical COVID associated with moderate-severe dyspnea after hospital discharge.Scientific reports · 2025Article
- Knowledge, attitudes, and practice about protective ventilation among physical therapists.PloS one · 2025Article
- Allogeneic 'off-the-shelf' SARS-CoV-2-specific adoptive T-cell therapy for refractory viral infection and end organ disease.Clinical & translational immunology · 2025Article
- Application of new ARDS guidelines at the bedside.Critical care science · 2025Article
- Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies.Critical care science · 2025Article
- Epidemiology, ventilation management and outcomes of COVID-19 ARDS patients versus patients with ARDS due to pneumonia in the Pre-COVID era.Respiratory research · 2024Observational
- COVID-19 death risk predictors in Brazil using survival tree analysis: a retrospective cohort from 2020 to 2022.International journal for equity in health · 2024Article
- Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 5% of COVID-19 patients develop respiratory failure and need ventilatory support, yet little is known about the impact of mechanical ventilation strategy in COVID-19. Our objective was to describe baseline characteristics, ventilatory parameters, and outcomes of critically ill patients in the largest referral center for COVID-19 in Sao Paulo, Brazil, during the first surge of the pandemic.
methodsThis cohort included COVID-19 patients admitted to the intensive care units (ICUs) of an academic hospital with 94 ICU beds, a number expanded to 300 during the pandemic as part of a state preparedness plan. Data included demographics, advanced life support therapies, and ventilator parameters. The main outcome was 28-day survival. We used a multivariate Cox model to test the association between protective ventilation and survival, adjusting for PF ratio, pH, compliance, and PEEP.
resultsWe included 1503 patients from March 30 to June 30, 2020. The mean age was 60 ± 15 years, and 59% were male. During 28-day follow-up, 1180 (79%) patients needed invasive ventilation and 666 (44%) died. For the 984 patients who were receiving mechanical ventilation in the first 24 h of ICU stay, mean tidal volume was 6.5 ± 1.3 mL/kg of ideal body weight, plateau pressure was 24 ± 5 cmH
conclusionsDuring the peak of the epidemic in Sao Paulo, critically ill patients with COVID-19 often required mechanical ventilation and mortality was high. Our findings revealed an association between mechanical ventilation strategy and mortality, highlighting the importance of protective ventilation for patients with COVID-19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.