Evidence map›Paper›PMID 34097119›Full record

ReviewApplied microbiology and biotechnology2021

Stress modulation as a means to improve yeasts for lignocellulose bioconversion.

B A Brandt, T Jansen, H Volschenk, J F Görgens, W H Van Zyl, R Den Haan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

B A BrandtDepartment of Microbiology, Stellenbosch University, Stellenbosch, South Africa.
T JansenDepartment of Microbiology, Stellenbosch University, Stellenbosch, South Africa.
H VolschenkDepartment of Microbiology, Stellenbosch University, Stellenbosch, South Africa.
J F GörgensDepartment of Process Engineering, Stellenbosch University, Stellenbosch, South Africa.
W H Van ZylDepartment of Microbiology, Stellenbosch University, Stellenbosch, South Africa.
R Den HaanDepartment of Biotechnology, University of the Western Cape, Bellville, South Africa. rdenhaan@uwc.ac.za.

Funding

National Research Foundation 111691National Research Foundation 86423
6 · The paper itself

Abstract

The second-generation (2G) fermentation environment for lignocellulose conversion presents unique challenges to the fermentative organism that do not necessarily exist in other industrial fermentations. While extreme osmotic, heat, and nutrient starvation stresses are observed in sugar- and starch-based fermentation environments, additional pre-treatment-derived inhibitor stress, potentially exacerbated by stresses such as pH and product tolerance, exist in the 2G environment. Furthermore, in a consolidated bioprocessing (CBP) context, the organism is also challenged to secrete enzymes that may themselves lead to unfolded protein response and other stresses. This review will discuss responses of the yeast Saccharomyces cerevisiae to 2G-specific stresses and stress modulation strategies that can be followed to improve yeasts for this application. We also explore published -omics data and discuss relevant rational engineering, reverse engineering, and adaptation strategies, with the view of identifying genes or alleles that will make positive contributions to the overall robustness of 2G industrial strains. KEYPOINTS: • Stress tolerance is a key driver to successful application of yeast strains in biorefineries. • A wealth of data regarding stress responses has been gained through omics studies. • Integration of this knowledge could inform engineering of fit for purpose strains.

Indexed as

LigninSaccharomyces cerevisiaeFermentationStarchYeastsLigninlignocelluloseStarchConsolidated bioprocessingSaccharomyces cerevisiaeSecond-generation biofuelStress modulation

Identifiers

PMID34097119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.