Evidence map›Paper›PMID 34097071›Full record

ArticleThe Journal of clinical endocrinology and metabolism2021

The Cortisol and ACTH Response to Dex/CRH Testing in Women With and Without Perimenopausal Depression.

Gioia M Guerrieri, Rivka Ben Dor, Xiaobai Li, Shau-Ming Wei, Pedro E Martinez, Lynnette K Neiman, David R Rubinow, Peter J Schmidt

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Gioia M GuerrieriBehavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Rivka Ben DorBehavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Xiaobai LiBiostatistics & Clinical Epidemiology Service, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Shau-Ming WeiBehavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Pedro E MartinezBehavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Lynnette K NeimanProgram in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, Bethesda, MD, USA.
David R RubinowDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Peter J SchmidtBehavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6565-0181
National Institutes of Health · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health Clinical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Psychobiology And Treatment Of Perimenopausal Mood DisordersZIAMH002537 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SCHMIDT, PETER · 2009 to 2025
$14.9M
Intramural NIH HHS ZIA MH002537NIMH NIH HHS ZIAMH002537
6 · The paper itself

Abstract

contextAbnormalities in the hypothalamic-pituitary-adrenal (HPA) axis are frequent accompaniments of depression, and studies have documented the role of stress and stressful life events in the ontogeny of perimenopausal depressions (PMD). Because HPA axis function in women is further modulated both by aging and ovarian steroids, it is possible that a dysregulated HPA axis contributes to the increased risk of PMD.

objectiveWe examined HPA axis function in perimenopausal women with and without depression using the combined dexamethasone-corticotropin-releasing hormone (Dex/CRH) test.

methodsDex/CRH tests were performed on 20 women with PMD and 20 women who were also perimenopausal but without current or past depression (control women). Main outcome measures were plasma levels of cortisol and adrenocorticotropin (ACTH) and 24-hour urinary free cortisol (UFC). Five women took chronic stable medications, otherwise all women were medically healthy, and both groups were comparable with respect to reproductive stage and age. Standardized symptom rating scales were administered to each woman prior to Dex/CRH testing.

resultsNo group differences were present in either baseline or stimulated ACTH and cortisol secretion. Baseline plasma measures of estradiol, progesterone, and 24-hour UFC levels similarly did not differ in PMD and control women.

conclusionDespite reports of increased stress responsiveness in PMD, we observed no abnormalities of HPA axis activity associated with PMD compared with women without depression. These findings suggest that PMD is not uniformly associated with HPA dysregulation and could reflect underlying pathophysiologic processes that are distinct from women with nonreproductive-related depressions.

Indexed as

Adrenocorticotropic HormoneAdultCorticotropin-Releasing HormoneDepressionDexamethasoneEstradiolFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMiddle AgedPerimenopausePituitary-Adrenal SystemProgesteroneAdrenocorticotropic HormoneCorticotropin-Releasing HormoneDexamethasoneEstradiolHydrocortisoneProgesteroneACTHcortisoldepressionDex/CRH testperimenopause

Identifiers

PMID34097071
PMCPMC8475231
OpenAlexW3167136453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.