Evidence map›Paper›PMID 34096836›Full record

ArticleHuman vaccines & immunotherapeutics2021

COVID-19 vaccine hesitancy: a survey in a population highly compliant to common vaccinations.

Flora Fedele, Massimo Aria, Valeria Esposito, Maria Micillo, Gaetano Cecere, Maria Spano, Giulio De Marco

Abstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  14. Parental hesitancy for pediatric COVID-19 vaccines in Chile.Therapeutic advances in vaccines and immunotherapy · 2025
    Article
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  16. Unveiling parental perspectives: COVID-19 vaccination for children in India.Journal of family medicine and primary care · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Flora FedeleDepartment of Pediatrics, University Federico II of Naples, Naples, Italy.
Massimo AriaDepartment of Economics and Statistics, University Federico II of Naples, Naples, Italy.
Valeria EspositoASL Napoli 2 Nord, Distretto Sanitario 43, Naples, Italy.
Maria MicilloASL Napoli 1 Centro, Distretto Sanitario 28, Naples, Italy.
Gaetano CecereASL Napoli 1 Centro, Distretto Sanitario 28, Naples, Italy.
Maria SpanoDepartment of Economics and Statistics, University Federico II of Naples, Naples, Italy.ORCID 0000-0002-3103-2342
Giulio De MarcoASL Napoli 1 Centro, Distretto Sanitario 28, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination is a key protective factor against COVID-19. Some vaccines have already received emergency authorization from Health Agencies, but growing skepticism and vaccine hesitancy will probably affect COVID-19 vaccination campaigns. In the attempt to shed light on this issue, we conducted an online survey in a population of parents referring to 4 pediatric practices in Naples, Italy in whom we evaluated potential vaccine acceptability in relation to socio-demographic characteristics, perception of personal health and of the impact of COVID-19, and attitudes toward general vaccination practices. Vaccination rates were analyzed also in the corresponding pediatric population.Almost 27% of participants declared they were in favor of vaccinations, and in fact real life vaccination rates in children exceeded the national mean. Only 26.5% of respondents declared they would receive COVID-19 vaccine. Vaccine refusal was attributed to safety concerns in 76% of parents. Specific vaccine attributes further reduced the acceptance rate. Female gender, younger age and lower education level were associated with non-adherence to vaccination. Among extrinsic factors of COVID-19 vaccination, only information from National Health Authorities was significantly associated to vaccine acceptance.The rate of potential COVID-19 vaccine acceptability was very poor in our population of parents. Vaccine hesitancy was mainly due to safety concerns. Demographic and educational factors were correlated to vaccine acceptability. Health education and communication strategies are needed to achieve large-scale vaccine acceptability and finally herd immunity.

Indexed as

COVID-19VaccinesChildCOVID-19 VaccinesCross-Sectional StudiesFemaleHumansSARS-CoV-2Surveys and QuestionnairesVaccinationCOVID-19 VaccinesVaccinesCOVID-19herd immunityparentsvaccination ratesvaccine hesitancy

Identifiers

PMID34096836
PMCPMC8437535

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.