Evidence map›Paper›PMID 34096779›Full record

ArticleJournal of bacteriology2021

Spore-Associated Proteins Involved in c-di-GMP Synthesis and Degradation of Bacillus anthracis.

Timothy M Hermanas, Sundharraman Subramanian, Charles E Dann, George C Stewart

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Biofilm Dispersal inMicroorganisms · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Timothy M Hermanas *Department of Veterinary Pathobiology, University of Missourigrid.134936.a, Columbia, Missouri, USA.
Sundharraman Subramanian *Department of Chemistry, Indiana University, Bloomington, Indiana, USA.
Charles E DannDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.
George C StewartDepartment of Veterinary Pathobiology, University of Missourigrid.134936.a, Columbia, Missouri, USA.
Indiana University Bloomington · USUniversity of Missouri · US

Funding

STRUCTURAL STUDIES IN THE CENTRAL NERVOUS SYSTEMP01AG000001 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 1985 to 2013
$20.7M
A cyclic di-GMP signaling system of spores of Bacillus anthracisR21AI112725 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI STEWART, GEORGE C. · 2015 to 2016
$413k
NIAID NIH HHS R21 AI112725NIAID NIH HHS R21AI112725NIA NIH HHS P01 AG000001
6 · The paper itself

Abstract

Bis-(3'-5')-cyclic-dimeric GMP (c-di-GMP) is an important bacterial regulatory signaling molecule affecting biofilm formation, toxin production, motility, and virulence. The genome of Bacillus anthracis, the causative agent of anthrax, is predicted to encode ten putative GGDEF/EAL/HD-GYP-domain containing proteins. Heterologous expression in Bacillus subtilis hosts indicated that there are five active GGDEF domain-containing proteins and four active EAL or HD-GYP domain-containing proteins. Using an mCherry gene fusion-Western blotting approach, the expression of the c-di-GMP-associated proteins was observed throughout the

Indexed as

Antigens, BacterialBacillus anthracisBacterial ProteinsBacterial ToxinsCyclic GMPGene Expression Regulation, BacterialProtein DomainsSpores, Bacterialanthrax toxinAntigens, BacterialBacterial ProteinsBacterial Toxinsbis(3',5')-cyclic diguanylic acidCyclic GMPanthrax toxinBacillus anthracisc-di-GMPexosporiumgerminationsporesporulation

Identifiers

PMID34096779
PMCPMC8351633
OpenAlexW3172769966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.