Evidence map›Paper›PMID 34096756›Full record

ArticleExperimental and clinical psychopharmacology2022

Wireless electroencephalography (EEG) to monitor sleep among patients being withdrawn from opioids: Evidence of feasibility and utility.

Kelly E Dunn, Patrick H Finan, Andrew S Huhn, Charlene Gamaldo, Cecilia L Bergeria, Eric C Strain

Open access · greenAbstract read
In one paragraph

Article in Experimental and clinical psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Sleep Health Among Adults in Outpatient Opioid Use Disorder Treatment: A Systematic Review.Journal of psychosocial nursing and mental health services · 2024
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kelly E DunnDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Patrick H FinanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.
Andrew S HuhnDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.ORCID 0000-0002-8073-7701
Charlene GamaldoDepartment of Neurology, Johns Hopkins University School of Medicine.ORCID 0000-0002-9386-9666
Cecilia L BergeriaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.ORCID 0000-0002-8183-1273
Eric C StrainDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine.ORCID 0000-0001-8482-5461
Johns Hopkins University · US

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
Evaluating the Role of the Orexin System in Circadian Rhythms of Sleep and Stress in Persons on Medication-Assisted Treatments for Opioid Use DisorderU01HL150835 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FINAN, PATRICK, HUHN, ANDREW S · 2019 to 2024
$5.3M
Medications Development for Drug Abuse DisordersR01DA018125 · NIDA · JOHNS HOPKINS UNIVERSITY · PI STRAIN, ERIC C. · 2004 to 2014
$5.2M
Using Cannabinoids to Enhance Opioid Analgesic Effects in HumansR01DA040644 · NIDA · JOHNS HOPKINS UNIVERSITY · PI CAMPBELL, CLAUDIA MICHELLE, DUNN, KELLY E · 2016 to 2021
$3.4M
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in HumansR01DA035246 · NIDA · JOHNS HOPKINS UNIVERSITY · PI DUNN, KELLY E · 2014 to 2018
$3.2M
Opioid and cannabinoid combinations in laboratory and clinical painR01DA042751 · NIDA · JOHNS HOPKINS UNIVERSITY · PI CAMPBELL, CLAUDIA MICHELLE, DUNN, KELLY E · 2017 to 2020
$2.2M
Evaluating Suvorexant for Sleep Disturbance in Opioid Use DisorderUG3DA048734 · NIDA · JOHNS HOPKINS UNIVERSITY · PI DUNN, KELLY E, HUHN, ANDREW S · 2019 to 2020
$2.2M
NHLBI NIH HHS U01 HL150835NIDA NIH HHS R01 DA018125NIDA NIH HHS R01 DA035246NIDA NIH HHS R01 DA040644NIDA NIH HHS R01 DA042751NIDA NIH HHS T32 DA007209NIDA NIH HHS UG3 DA048734
6 · The paper itself

Abstract

Sleep impairment is a common comorbid and debilitating symptom for persons with opioid use disorder (OUD). Research into underlying mechanisms and efficacious treatment interventions for OUD-related sleep problems requires both precise and physiologic measurements of sleep-related outcomes and impairment. This pilot examined the feasibility of a wireless sleep electroencephalography (EEG) monitor (Sleep Profiler™) to measure sleep outcomes and architecture among participants undergoing supervised opioid withdrawal. Sleep outcomes were compared to a self-reported sleep diary and opioid withdrawal ratings. Participants (n = 8, 100% male) wore the wireless EEG 85.6% of scheduled nights. Wireless EEG detected measures of sleep architecture including changes in total, NREM and REM sleep time during study phases, whereas the diary detected changes in wakefulness only. Direct comparisons of five overlapping outcomes revealed lower sleep efficiency and sleep onset latency and higher awakenings and time spent awake from the wireless EEG versus sleep diary. Associations were evident between wireless EEG and increased withdrawal severity, lower sleep efficiency, less time in REM and non-REM stages 1 and 2, and more hydroxyzine treatment; sleep diary was associated with total sleep time and withdrawal only. Data provide initial evidence that a wireless EEG is a feasible and useful tool for objective monitoring of sleep in persons experiencing acute opioid withdrawal. Data are limited by the small and exclusively male sample, but provide a foundation for using wireless EEG sleep monitors for objective evaluation of sleep-related impairment in persons with OUD in support of mechanistic and treatment intervention research. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Indexed as

Analgesics, OpioidOpioid-Related DisordersElectroencephalographyFeasibility StudiesFemaleHumansMaleSleepSleep, REMWakefulnessAnalgesics, Opioid

Identifiers

PMID34096756
PMCPMC8648854
OpenAlexW3167920053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.