ArticleJournal of veterinary internal medicine2021
Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: A retrospective study.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Clinical findings and risk factors for clinical outcomes in dogs with myxomatous mitral valve disease hospitalized for cardiogenic pulmonary edema.Frontiers in veterinary science · 2026Article
- Copeptin Hormone Concentrations in Dogs with Heart Disease and Relationship with Antidiuretic Hormone.Animals : an open access journal from MDPI · 2025Article
- Occurrence of cardiovascular events in 168 cats with acute urinary tract obstruction.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- The Prognostic Utility of Venous Blood Gas Analyses at Presentation in Cats with Cardiogenic Pulmonary Edema.Veterinary sciences · 2023Article
- Toward quantification of loop diuretic responsiveness for congestive heart failure.Journal of veterinary internal medicine · 2023Review
- Machine learning-based risk prediction model for canine myxomatous mitral valve disease using electronic health record data.Frontiers in veterinary science · 2023Article
- Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left-sided congestive heart failure in dogs.Journal of veterinary internal medicine · 2022Article
- Serum Chloride Is Inversely Associated With 3 Months Outcomes in Chinese Patients With Heart Failure, a Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2022Article
- Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: A retrospective study.Journal of veterinary internal medicine · 2021Article
- Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure.Journal of veterinary internal medicineArticle
- Frequency and progression of azotemia during acute and chronic treatment of congestive heart failure in cats.Journal of veterinary internal medicineArticle
- Clinical relevance of serum ionized magnesium concentration in dogs with myxomatous mitral valve disease.Journal of veterinary internal medicineArticle
- Retrospective Evaluation of the Prevalence and Prognosis of Hypochloremia in Dogs and Cats.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
- Use of serum osmolality to identify heart disease stage in dogs and relationship to mathematical chloride correction.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypochloremia is a strong negative prognostic factor in humans with congestive heart failure (CHF), but the implications of electrolyte abnormalities in small animals with acute CHF are unclear.
objectivesTo document electrolyte abnormalities present upon admission of small animals with acute CHF, and to assess the relationship between electrolyte concentrations and diuretic dose, duration of hospitalization and survival time. ANIMALS: Forty-six dogs and 34 cats with first onset of acute CHF.
methodsRetrospective study. The associations between electrolyte concentrations and diuretic doses were evaluated with Spearman rank correlation coefficients. Relationship with duration of hospitalization and survival were assessed by simple linear regression and Cox proportional hazard regression, respectively.
resultsThe most commonly encountered electrolyte anomaly was hypochloremia observed in 24% (9/46 dogs and 10/34 cats) of cases. In dogs only, a significant negative correlation was identified between serum chloride concentrations at admission (median 113 mmol/L [97-125]) and furosemide doses both at discharge (median 5.2 mg/kg/day [1.72-9.57]; r = -0.59; P < .001) and at end-stage heart failure (median 4.7 mg/kg/day [2.02-7.28]; r = -0.62; P = .005). No significant hazard ratios were found for duration of hospitalization nor survival time for any of the electrolyte concentrations. CONCLUSIONS AND CLINICAL IMPORTANCE: The observed association between serum chloride concentrations and diuretic doses suggests that hypochloremia could serve as a marker of disease severity and therapeutic response in dogs with acute CHF.
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