ArticleJournal of cell science2021
Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae.
Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Comparative Genomic and Transcriptomic Analyses ofLife (Basel, Switzerland) · 2026Article
- The Alleviating Effect of Arginine on Ethanol Stress inJournal of fungi (Basel, Switzerland) · 2025Article
- Spermidine toxicity in Saccharomyces cerevisiae due to mitochondrial complex III deficiency.Biogerontology · 2025Article
- Spermidine enhances the heat tolerance ofApplied and environmental microbiology · 2025Article
- Comparison of stress tolerance mechanisms between Saccharomyces cerevisiae and the multistress-tolerant Pichia kudriavzevii.FEMS yeast research · 2025Review
- Mitophagy in yeast: known unknowns and unknown unknowns.The Biochemical journal · 2023Review
- Current opinions on mitophagy in fungi.Autophagy · 2023Review
- Role of AMPK in autophagy.Frontiers in physiology · 2022Review
- Review
- Mitophagy in Yeast: Decades of Research.Cells · 2021Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, the selective autophagic degradation of mitochondria, termed mitophagy, is critically regulated by the adapter protein Atg32. Despite our knowledge about the molecular mechanisms by which Atg32 controls mitophagy, its physiological roles in yeast survival and fitness remains less clear. Here, we demonstrate a requirement for Atg32 in promoting spermidine production during respiratory growth and heat-induced mitochondrial stress. During respiratory growth, mitophagy-deficient yeast exhibit profound heat-stress induced defects in growth and viability due to impaired biosynthesis of spermidine and its biosynthetic precursor S-adenosyl methionine. Moreover, spermidine production is crucial for the induction of cytoprotective nitric oxide (NO) during heat stress. Hence, the re-addition of spermidine to Atg32 mutant yeast is sufficient to both enhance NO production and restore respiratory growth during heat stress. Our findings uncover a previously unrecognized physiological role for yeast mitophagy in spermidine metabolism and illuminate new interconnections between mitophagy, polyamine biosynthesis and NO signaling.
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