Observational studyJournal of the American Heart Association2021
Exercise-Based Cardiac Rehabilitation and All-Cause Mortality Among Patients With Atrial Fibrillation.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- Efficacy of exercise intervention for atrial fibrillation: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Effect of exercise intervention on quality of life and exercise capacity in patients with atrial fibrillation: a systematic review and network meta-analysis.Frontiers in public health · 2025Pooled it
- Exercise-based cardiac rehabilitation for adults with atrial fibrillation.The Cochrane database of systematic reviews · 2024Pooled it
- Guideline
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- The impact of cardiac rehabilitation exercises incorporating music movement therapy on atrial fibrillation patients: a forward-looking investigation.Journal of cardiothoracic surgery · 2025Trial
- Impact of patient phenotype on the relationship between accelerometer-derived physical activity and cardiovascular events in atrial fibrillation.American journal of preventive cardiology · 2026Article
- Effect of Cardiac Rehabilitation on Cardiovascular Events in Patients With Advanced Chronic Kidney Disease.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025Article
- Cardiovascular and Oncologic Considerations in Adult Hodgkin Lymphoma: JACC: CardioOncology State-of the-Art Review.JACC. CardioOncology · 2025Review
- Cardiac Rehabilitation in the Modern Era: Evidence, Equity, and Evolving Delivery Models Across the Cardiovascular Spectrum.Journal of clinical medicine · 2025Review
- Temporal Trends in the Association Between Female Sex and Ischemic Stroke Among Patients With Atrial Fibrillation.Journal of the American Heart Association · 2025Article
- Exercise-based cardiac rehabilitation for patients with atrial fibrillation: a narrative review.European heart journal open · 2025Review
- Morbidity and mortality risks associated with valproate withdrawal in young adults with epilepsy.Brain : a journal of neurology · 2024Article
- Review
- Racial and Gender Differences in Cardiorespiratory Fitness and Atrial Fibrillation.Reviews in cardiovascular medicine · 2024Review
- Cardiac rehabilitation and adverse events among adult patients with simple congenital heart disease and heart failure.American journal of preventive cardiology · 2024Article
- A New Player in the Game: Can Exergame Be of Support in the Management of Atrial Fibrillation?Medicina (Kaunas, Lithuania) · 2024Review
- Effect of physical exercise on metabolism in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2024Review
- Cardiac telerehabilitation: current status and future perspectives.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background There is limited evidence of long-term impact of exercise-based cardiac rehabilitation (CR) on clinical end points for patients with atrial fibrillation (AF). We therefore compared 18-month all-cause mortality, hospitalization, stroke, and heart failure in patients with AF and an electronic medical record of exercise-based CR to matched controls. Methods and Results This retrospective cohort study included patient data obtained on February 3, 2021 from a global federated health research network. Patients with AF undergoing exercise-based CR were propensity-score matched to patients with AF without exercise-based CR by age, sex, race, comorbidities, cardiovascular procedures, and cardiovascular medication. We ascertained 18-month incidence of all-cause mortality, hospitalization, stroke, and heart failure. Of 1 366 422 patients with AF, 11 947 patients had an electronic medical record of exercise-based CR within 6-months of incident AF who were propensity-score matched with 11 947 patients with AF without CR. Exercise-based CR was associated with 68% lower odds of all-cause mortality (odds ratio, 0.32; 95% CI, 0.29-0.35), 44% lower odds of rehospitalization (0.56; 95% CI, 0.53-0.59), and 16% lower odds of incident stroke (0.84; 95% CI, 0.72-0.99) compared with propensity-score matched controls. No significant associations were shown for incident heart failure (0.93; 95% CI, 0.84-1.04). The beneficial association of exercise-based CR on all-cause mortality was independent of sex, older age, comorbidities, and AF subtype. Conclusions Exercise-based CR among patients with incident AF was associated with lower odds of all-cause mortality, rehospitalization, and incident stroke at 18-month follow-up, supporting the provision of exercise-based CR for patients with AF.
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Registered trials
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