Evidence map›Paper›PMID 34096318›Full record

ArticleJournal of the American Heart Association2021

Magnesium Deficiency Causes a Reversible, Metabolic, Diastolic Cardiomyopathy.

Man Liu, Hong Liu, Feng Feng, An Xie, Gyeoung-Jin Kang, Yang Zhao, Cody R Hou, Xiaoxu Zhou, Samuel C Dudley

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Redox Control in Platelet Activity and Therapy.Antioxidants (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Magnesium-A More Important Role in CKD-MBD than We Thought.Diagnostics (Basel, Switzerland) · 2022
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Man LiuDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Hong LiuDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Feng FengDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
An XieDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Gyeoung-Jin KangDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Yang ZhaoDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Cody R HouDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Xiaoxu ZhouDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
Samuel C DudleyDivision of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota at Twin Cities Minneapolis MN.
University of Minnesota · US

Funding

Research Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8M
Na+ channel mRNA splicing in heart failureR01HL104025 · NHLBI · UNIVERSITY OF MINNESOTA · PI DUDLEY, SAMUEL C · 2011 to 2019
$3.3M
Metabolic Regulation of Sodium ChannelsR01HL106592 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDLEY, SAMUEL C · 2011 to 2014
$1.6M
NHLBI NIH HHS R01 HL104025NHLBI NIH HHS R01 HL106592NIGMS NIH HHS T32 GM007592
6 · The paper itself

Abstract

Background Dietary Mg intake is associated with a decreased risk of developing heart failure, whereas low circulating Mg level is associated with increased cardiovascular mortality. We investigated whether Mg deficiency alone could cause cardiomyopathy. Methods and Results C57BL/6J mice were fed with a low Mg (low-Mg, 15-30 mg/kg Mg) or a normal Mg (nl-Mg, 600 mg/kg Mg) diet for 6 weeks. To test reversibility, half of the low-Mg mice were fed then with nl-Mg diet for another 6 weeks. Low-Mg diet significantly decreased mouse serum Mg (0.38±0.03 versus 1.14±0.03 mmol/L for nl-Mg;

Indexed as

Myocardial ContractionVentricular Function, LeftAdenosine TriphosphateAnimalsAntioxidantsCalcium SignalingCardiomyopathiesCarrier ProteinsDiastoleDisease Models, AnimalMagnesium DeficiencyMiceMice, Inbred C57BLMitochondria, HeartMyocytes, CardiacMyosin Binding Protein CAdenosine TriphosphateAntioxidantsCarrier ProteinsMitoTEMPOMyosin Binding Protein COrganophosphorus CompoundsPiperidinesReactive Oxygen SpeciesCa handlingdiastolic dysfunctionhypomagnesemiamitochondrial dysfunction

Identifiers

PMID34096318
PMCPMC8477865
OpenAlexW3173097919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.