ArticleInternational journal of implant dentistry2021
Osteoconductive properties of upside-down bilayer collagen membranes in rat calvarial defects.
Article in International journal of implant dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Optical Coherence Tomography, Stereomicroscopic, and Histological Aspects of Bone Regeneration on Rat Calvaria in the Presence of Bovine Xenograft or Titanium-Reinforced Hydroxyapatite.Journal of functional biomaterials · 2026Article
- Higher solubility and lower onset temperature of protein denaturation increase the osteoconductive capacity of collagen membranes: A preclinical in vivo study.Clinical oral implants research · 2024Article
- Human versus Rat PRF on Collagen Membranes: A Pilot Study of Mineralization in Rat Calvaria Defect Model.Bioengineering (Basel, Switzerland) · 2024Article
- Active and Passive Mineralization of Bio-GideJournal of functional biomaterials · 2024Article
- Osteogenic human MSC-derived extracellular vesicles regulate MSC activity and osteogenic differentiation and promote bone regeneration in a rat calvarial defect model.Stem cell research & therapy · 2024Article
- Effectiveness of a collagen matrix seal and xenograft in alveolar ridge preservation: an experimental study in dogs.Scientific reports · 2024Article
- Article
- Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region.ACS applied bio materials · 2023Review
- Properties of three collagen scaffolds in comparison with native connective tissue: an in-vitro study.International journal of implant dentistry · 2023Article
- Article
- Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects.Molecules (Basel, Switzerland) · 2022Article
- Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study.Biomedicines · 2021Article
- Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs.Frontiers in bioengineering and biotechnology · 2021Article
- Layered scaffolds in periodontal regeneration.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBilayer collagen membranes are routinely used in guided bone/tissue regeneration to serve as osteoconductive scaffolds and prevent the invasion of soft tissues. It is recommended to place the membranes with their dense layer towards the soft tissue and their porous layer towards the bony defect area. However, evidence supporting this recommendation is lacking. This study aimed to determine whether the alignment of bilayer collagen membranes has an effect on bone regeneration.
methodsIn two groups of ten male Sprague-Dawley rats each, a 5-mm calvarial defect was created. Thereafter, the defect was randomly covered with a bilayer, resorbable, pure type I and III collagen membrane placed either regularly or upside-down (i.e., dense layer towards bone defect). After 4 weeks of healing, micro-computed tomography (μCT), histology, and histomorphometry of the inner cylindrical region of interest (4.5 mm in diameter) were performed to assess new bone formation and the consolidation of the collagen membrane in the defect area.
resultsQuantitative μCT showed similar bone volume (median 8.0 mm
conclusionsOur data support the osteoconductive properties of collagen membranes and suggest that bone regeneration is facilitated regardless of membrane layer alignment.
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Registered trials
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