ArticlePhysical chemistry chemical physics : PCCP2021
Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids.
Article in Physical chemistry chemical physics : PCCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 20 citations in OpenAlex.
- Borate-Guanosine Hydrogels and Their Hypothetical Participation in the Prebiological Selection of Ribonucleoside Anomers: A Computational (DFT) Study.International journal of molecular sciences · 2025Article
- Amorphous aggregates with a very wide size distribution play a central role in crystal nucleation.Chemical science · 2024Article
- Hydration water drives the self-assembly of guanosine monophosphate.Biophysical journal · 2024Article
- Lifting Hofmeister's Curse: Impact of Cations on Diffusion, Hydrogen Bonding, and Clustering of Water.Journal of the American Chemical Society · 2024Article
- Understanding the emergence of the boson peak in molecular glasses.Nature communications · 2023Article
- Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code.International journal of molecular sciences · 2022Review
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5 authors at 1 institution in 1 country.
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Abstract
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA-protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands of DNA) and B-DNA characterized using femtosecond optical Kerr-effect spectroscopy. Contrary to expectation, we found that G-quadruplexes show several strongly underdamped delocalized phonon-like modes that have the potential to contribute to the biology of the DNA at the atomic level. In addition, G-quadruplexes present modes at a higher frequency than B-DNA demonstrating that changes in the stiffness of the molecule alter its gigahertz to terahertz vibrational profile.
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