ArticleIBRO neuroscience reports2021
Chronic pain-related cortical neural activity in patients with complex regional pain syndrome.
Article in IBRO neuroscience reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Pooled it
- Altered neuromagnetic activity under visual stimuli in migraine: a multi-frequency magnetoencephalography study.Frontiers in neurology · 2025Article
- Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review.BMJ neurology open · 2025Article
- Imbalance in positive and negative acceleration ratio of alpha oscillation in patients with complex regional pain syndrome.Heliyon · 2024Article
- Brain-wide network analysis of resting-state neuromagnetic data.Human brain mapping · 2023Article
- Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation.Scientific reports · 2023Article
- Glomus Tumor of the Lower Extremity Previously Misdiagnosed as Complex Regional Pain Syndrome in Close Proximity to a Myxofibrosarcoma: A Case Report.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Exercise therapy for chronic pain: How does exercise change the limbic brain function?Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative objective measurement of chronic pain is important. We elucidated chronic pain-related cortical neural activity and neural connectivity among pain-related brain regions in complex regional pain syndrome (CRPS). Resting-state magnetoencephalography recordings were performed. Cortical current density and neural connectivity, revealed by amplitude envelope correlation (AEC), were estimated on standardized brain magnetic resonance imaging. Intra-experiment pain was assessed subjectively using a visual analogue scale (VAS). The correlation between current density and VAS scores was calculated for the occipital areas and pain-related cortices. Current density in the primary (SI) and secondary (SII) somatosensory cortex and precuneus in both hemispheres was negatively correlated with the pain VAS score. The AEC and VAS values were significantly correlated for the SII and the precuneus and for the SII and insular cortex in the alpha frequency band in the right hemisphere. In the theta frequency band, the AEC and VAS values correlated for the SII and posterior cingulate cortex in the right hemisphere. Our results suggested that disruption of pain processes and functions in the default mode network occurs in CRPS. Our method targeting the neural mechanism of pain has the potential to offer a clinically objective means of evaluating it.
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