Evidence map›Paper›PMID 34095887›Full record

ArticleCell reports. Medicine2021

Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis.

Intan M W Dewi, Cristina Cunha, Martin Jaeger, Mark S Gresnigt, Marina E Gkountzinopoulou, Fadel M Garishah, Cláudio Duarte-Oliveira, Cláudia F Campos, Lore Vanderbeke, Agustin Resendiz Sharpe and 11 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Towards a holistic approach to pulmonary infections. Insights from the Sixth Annual Meeting of Spanish Experts 2024.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Immunity to fungi in the lung.Seminars in immunology · 2023
    Review
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  15. Article
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Intan M W DewiDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Cristina CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Martin JaegerDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Mark S GresnigtDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoll Institute, Jena, Germany.
Marina E GkountzinopoulouDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Fadel M GarishahDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Cláudio Duarte-OliveiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Cláudia F CamposLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Lore VanderbekeDepartment of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Agustin Resendiz SharpeDepartment of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Roger J BrüggemannDepartment of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands.
Paul E VerweijDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Katrien LagrouDepartment of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Greetje Vande VeldeBiomedical MRI/Molecular Small Animal Imaging Center, Department of Imaging and Pathology, KU Leuven, Belgium.
Quirijn de MastDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Leo A B JoostenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Andre J A M van der VenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Joost WautersDepartment of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Agostinho CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Frank L van de VeerdonkDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza-associated pulmonary aspergillosis (IAPA) has been reported increasingly since the advent of use of neuraminidase (NA) inhibitors following the 2009 influenza pandemic. We hypothesize that blocking host NA modulates the immune response against

Indexed as

AnimalsAntiviral AgentsAspergillusAspergillus fumigatusHumansImmunoglobulinsLeukocytes, MononuclearLungMembrane ProteinsMiceMice, Inbred C57BLNeuraminidaseOseltamivirPhagocytosisPulmonary AspergillosisAntiviral AgentsImmunoglobulinsMembrane ProteinsNeuraminidaseOseltamivirSIGLEC15 protein, humanaspergillosisneuraminidaseoseltamivirSIGLEC15

Identifiers

PMID34095887
PMCPMC8149467

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.