ArticleCell reports. Medicine2021
Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection.
Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The epidemiologic and economic burden of dengue in Singapore: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Functional antibody responses and protection against symptomatic dengue.Communications medicine · 2026Review
- Dengue infection elicits skin tissue-resident and circulating CD8Science advances · 2026Article
- Research progress of dengue virus T cell epitope mediated cellular immunity in avoiding ADE.Frontiers in immunology · 2026Review
- T Cell Responses During Dengue Infection.Current topics in microbiology and immunology · 2026Review
- Dengue Fever and Its Burden in Burkina Faso: An Overview.Reviews in medical virology · 2026Review
- Virus-like Particles and Spectral Flow Cytometry for Identification of Dengue Virus-Specific B Cells in Mice and Humans.Viruses · 2025Article
- Dengue and severe dengue.Clinical microbiology reviews · 2025Review
- Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue.Cell host & microbe · 2025Article
- Functionality and phenotype of T cells in patients with varying severity of acute dengue and metabolic status.medRxiv : the preprint server for health sciences · 2025Article
- Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight.Nature communications · 2025Article
- Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection.Cell reports · 2025Article
- Balancing functions of regulatory T cells in mosquito-borne viral infections.Emerging microbes & infections · 2024Review
- Article
- Dengue.Lancet (London, England) · 2024Review
- Emerging insights into atypical B cells in pediatric chronic infectious diseases and immune system disorders: T(o)-bet on control of B-cell immune activation.The Journal of allergy and clinical immunology · 2024Review
- Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever.Journal of biomedical science · 2023Article
- Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics.Science advances · 2023Article
- Flying under the radar - impact and factors influencing asymptomatic DENV infections.Frontiers in cellular and infection microbiology · 2023Review
- A nonstructural protein 1 capture enzyme-linked immunosorbent assay specific for dengue viruses.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody responses in the same patients. Antibody responses as well as T and B cell activation differentiate primary from secondary responses. Hospitalization is associated with lower frequencies of activated, terminally differentiated T cells and higher percentages of effector memory CD4 T cells. Patients with more severe disease tend to have higher percentages of plasmablasts. This does not translate into long-term antibody titers, since neutralizing titers after 6 months correlate with percentages of specific memory B cells, but not with acute plasmablast activation. Overall, our unbiased analysis reveals associations between cellular profiles and disease severity, opening opportunities to study immunopathology in dengue disease and the potential predictive value of these parameters.
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