Evidence map›Paper›PMID 34095872›Full record

ReviewCell reports. Medicine2021

Knee orthopedics as a template for the temporomandibular joint.

Benjamin J Bielajew, Ryan P Donahue, M Gabriela Espinosa, Boaz Arzi, Dean Wang, David C Hatcher, Nikolaos K Paschos, Mark E K Wong, Jerry C Hu, Kyriacos A Athanasiou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Mastication-Induced Electrical Stimulation Activates Prg4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  10. Comparative review: clinical and pathological heterogeneity in kneeFrontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Benjamin J BielajewDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Ryan P DonahueDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
M Gabriela EspinosaDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Boaz ArziDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Dean WangDepartment of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
David C HatcherDiagnostic Digital Imaging Center, Sacramento, CA, USA.
Nikolaos K PaschosDepartment of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mark E K WongDepartment of Oral and Maxillofacial Surgery, University of Texas School of Dentistry, Houston, TX, USA.
Jerry C HuDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · USHarvard University · USImaging Center · USUniversity of California, Davis · USUniversity of California, Irvine Medical Center · US

Funding

TMJ Disc RegenerationR01DE015038 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2004 to 2022
$6.1M
Self-assembling process in tissue engineering of articular cartilageR01AR067821 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2015 to 2019
$1.9M
Engineering biomimetic knee menisci with zonal and anisotropic variationsR01AR071457 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2017 to 2021
$1.8M
NIAMS NIH HHS R01 AR067821NIAMS NIH HHS R01 AR071457NIDCR NIH HHS R01 DE015038
6 · The paper itself

Abstract

Although the knee joint and temporomandibular joint (TMJ) experience similar incidence of cartilage ailments, the knee orthopedics field has greater funding and more effective end-stage treatment options. Translational research has resulted in the development of tissue-engineered products for knee cartilage repair, but the same is not true for TMJ cartilages. Here, we examine the anatomy and pathology of the joints, compare current treatments and products for cartilage afflictions, and explore ways to accelerate the TMJ field. We examine disparities, such as a 6-fold higher article count and 2,000-fold higher total joint replacement frequency in the knee compared to the TMJ, despite similarities in osteoarthritis incidence. Using knee orthopedics as a template, basic and translational research will drive the development and implementation of clinical products for the TMJ. With more funding opportunities, training programs, and federal guidance, millions of people afflicted with TMJ disorders could benefit from novel, life-changing therapeutics.

Indexed as

Cartilage, ArticularHumansKnee JointOsteoarthritisTemporomandibular JointTemporomandibular Joint DiscTemporomandibular Joint Disorderscartilageknee jointoral and maxillofacial surgeryorthopedic surgeryosteoarthritistemporomandibular disordertemporomandibular jointtissue engineeringTMJ disctranslational medicine

Identifiers

PMID34095872
PMCPMC8149366
OpenAlexW3156142220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.